TEAD2 Antibody
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In Stock 
Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days after receiving it. Delivery time may vary depending on the shipping method and destination. Please consult your local distributor for specific delivery timeframes.
Synonyms
Embryonic TEA domain containing factor antibody; Etdf antibody; ETEF 1 antibody; ETF antibody; TEA domain family member 2 antibody; TEAD 2 antibody; TEAD-2 antibody; TEAD2 antibody; Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b) antibody; TEAD2_HUMAN antibody; TEF 4 antibody; TEF4 antibody; Transcriptional enhancer factor 4 antibody; Transcriptional enhancer factor TEF 4 antibody; Transcriptional enhancer factor TEF-4 antibody
Target Names
Uniprot No.
Target Background
Function
TEAD2 is a transcription factor playing a crucial role in the Hippo signaling pathway. This pathway regulates organ size and suppresses tumor development by controlling cell proliferation and promoting apoptosis. The core of the Hippo pathway involves a kinase cascade, where MST1/MST2, in complex with SAV1, phosphorylates and activates LATS1/2, which is in complex with MOB1. This activation leads to the phosphorylation and inactivation of YAP1 oncoprotein and WWTR1/TAZ. TEAD2 mediates gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration, and epithelial mesenchymal transition (EMT). It binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). TEAD2 may also be involved in gene regulation during neural development and binds to the M-CAT motif.
Gene References Into Functions
- TAZ negatively regulates the transcription of DeltaNp63 through TEAD1,2,3 and 4 transcription factors. PMID: 25995450
- This study provides structural and functional analysis of the YAP-binding domain of human TEAD2. PMID: 20368466
Database Links
Subcellular Location
Nucleus.
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