ten-1 Antibody
Description
Introduction to Ten-1 Antibody
Ten-1 (Teneurin-1, TENM1) is a cytoskeletal protein critical for neural development, synaptic plasticity, and stress response modulation. It localizes to focal adhesions and regulates neuroplasticity in limbic structures, influencing dendritic arborization and spine density . The Ten-1 antibody is a research tool used to study its expression, localization, and functional roles in neurobiology and disease models.
Key Antibody Properties
*Theoretical MW of the immunogen peptide; observed MW may vary due to post-translational modifications .
Neural Development and Plasticity
Ten-1 regulates proper neural connectivity and dendritic remodeling. It induces BDNF transcription inhibition and activates the MAPK/ERK cascade, promoting neuroplasticity in hippocampal and amygdalar neurons . Antibodies targeting Ten-1 have been used to study its role in stress-induced behaviors, including cocaine-seeking reinstatement and corticotropin-releasing factor (CRF)-mediated responses .
Neuroprotective Mechanisms
Ten-1’s intracellular domain exhibits neuroprotective effects, attenuating alkalosis-associated necrotic cell death and mitigating CRF’s impact on c-fos expression . These findings suggest Ten-1 antibodies could aid in exploring therapeutic strategies for neurodegenerative disorders.
Tissue-Specific Expression
Proteintech’s 21696-1-AP antibody detects Ten-1 in human and mouse brain tissues, with optimal antigen retrieval via TE buffer (pH 9.0) . In Western blot, R&D Systems’ AF6324 identifies a ~65 kDa band in IMR-32 neuroblastoma and HEK293 cells, indicating potential post-translational processing .
Species Reactivity and Cross-Specificity
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Abcam’s ab211297: Human/mouse-specific, validated for IHC and ICC .
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Proteintech’s 21696-1-AP: Broad reactivity (human/mouse/rat), suitable for multi-species studies .
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Bio-Techne’s NBP3-10120: Mouse-exclusive, ideal for murine model research .
Technical Limitations
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- Genetic interactions between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 are essential for collagen IV-mediated basement membrane integrity during late elongation of the embryo. (PMID: 21795395)
- Research findings suggest that ten-1 functions complementarily with cytoskeletal remodeling processes that occur in migrating cells or cells undergoing morphogenesis. (PMID: 20497576)
- TEN-1 acts as a receptor for morphogenetic cues and directly signals to the nucleus by translocating its intracellular domain to the nucleus following proteolytic release from the cell membrane. (PMID: 15936327)
- ten-1 is essential for gonadal and pharyngeal basement membrane integrity and functions redundantly with integrin ina-1 and dystroglycan dgn-1. (PMID: 18632986)
STRING: 6239.R13F6.4e
UniGene: Cel.10175
