TES Human
Description
Introduction to TES Gene
The TES gene in humans is involved in various cellular processes, and its study often requires specific tools like siRNA for gene silencing. The TES Human Pre-designed siRNA Set A is a tool used in molecular biology research to study the function of the TES gene by knocking down its expression .
Role of siRNA in Gene Expression
Small Interfering RNA (siRNA) is a powerful tool used to silence gene expression. It works by targeting specific mRNA sequences, leading to their degradation and preventing protein synthesis. The TES Human Pre-designed siRNA Set A includes three siRNAs designed to target the TES gene, along with controls for experimental validation .
Research Applications
The use of siRNA sets like the TES Human Pre-designed siRNA Set A is crucial in understanding gene function and its implications in disease models. By knocking down the TES gene, researchers can study its role in cellular processes and potential disease mechanisms.
Data and Findings
While specific data on the TES gene's function is limited in the provided sources, siRNA technology is widely used to study gene functions. Here is a general overview of how siRNA sets are used in research:
| Component | Description | Purpose |
|---|---|---|
| siRNA 1 | Targeted sequence 1 | Gene silencing |
| siRNA 2 | Targeted sequence 2 | Gene silencing |
| siRNA 3 | Targeted sequence 3 | Gene silencing |
| Negative Control | Non-targeting sequence | Experimental control |
| Positive Control | Known effective siRNA | Validation of siRNA delivery |
| FAM-labeled siRNA | Fluorescently labeled siRNA | Tracking siRNA delivery |
Product Specs
MGSSHHHHHH SSGLVPRGSH MDLENKVKKM GLGHEQGFGA PCLKCKEKCE GFELHFWRKI CRNCKCGQEE HDVLLSNEED RKVGKLFEDT KYTTLIAKLK SDGIPMYKRN VMILTNPVAA KKNVSINTVT YEWAPPVQNQ ALARQYMQML PKEKQPVAGS EGAQYRKKQL AKQLPAHDQD PSKCHELSPR EVKEMEQFVK KYKSEALGVG DVKLPCEMDA QGPKQMNIPG GDRSTPAAVG AMEDKSAEHK RTQYSCYCCK LSMKEGDPAI YAERAGYDKL WHPACFVCST CHELLVDMIY FWKNEKLYCG RHYCDSEKPR CAGCDELIFS NEYTQAENQN WHLKHFCCFD CDSILAGEIY VMVNDKPVCK PCYVKNHAVV CQGCHNAIDP EVQRVTYNNF SWHASTECFL CSCCSKCLIG QKFMPVEGMV FCSVECKKRM S.
Product Science Overview
The testis is a vital organ in the male reproductive system, responsible for the production of sperm and the synthesis of hormones essential for male sex characteristics. The testis-specific proteome is a complex and highly specialized collection of proteins that play crucial roles in spermatogenesis and hormone production. Among these proteins, the testis-derived transcript (human recombinant) is of particular interest due to its unique expression patterns and functions.
The human testis-specific proteome has been extensively studied using transcriptomics and antibody-based profiling. Transcriptome analysis reveals that approximately 77% of all human proteins are expressed in the testis, with 1992 genes showing elevated expression compared to other tissues . This elevated expression can be categorized into three subtypes: tissue-enriched, group-enriched, and tissue-enhanced . The testis has the highest number of tissue-specific genes, indicating its unique and specialized functions .
The primary function of the testis is to produce haploid germ cells necessary for reproduction. This process, known as spermatogenesis, involves a series of highly coordinated events that occur within the seminiferous ducts . Spermatogonial stem cells divide mitotically to form spermatogonia, which then undergo several rounds of mitosis to develop into primary and secondary spermatocytes. These spermatocytes divide by meiosis to form spermatids, which eventually differentiate into sperm .
In addition to spermatogenesis, the testis also produces hormones, such as testosterone, which are crucial for the development of male sex characteristics. Leydig cells, located outside the seminiferous ducts, are responsible for hormone synthesis .
The testis-derived transcript (human recombinant) refers to a specific mRNA or protein that is produced recombinantly in a laboratory setting. Recombinant proteins are typically produced by inserting the gene encoding the protein of interest into a suitable expression system, such as bacteria, yeast, or mammalian cells. This allows for the large-scale production of the protein for research or therapeutic purposes.
In the context of the testis, recombinant proteins can be used to study the functions of testis-specific genes and their roles in spermatogenesis and hormone production. For example, recombinant proteins can be used to investigate the localization and function of specific proteins within the testis, as well as their interactions with other proteins and cellular components .
The study of testis-derived transcripts and recombinant proteins has significant implications for understanding male reproductive biology and developing treatments for male infertility. By characterizing the molecular components of the testis, researchers can identify potential targets for therapeutic intervention and develop strategies to enhance or restore fertility.
Furthermore, the use of recombinant proteins in research allows for the detailed investigation of protein functions and interactions, providing valuable insights into the complex processes that govern spermatogenesis and hormone production. As our understanding of the testis-specific proteome continues to grow, new opportunities for therapeutic development and clinical applications will emerge.
