TESC Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Stored at -20°C. Avoid repeated freeze-thaw cycles.
Lead Time
Typically, we can ship your order within 1-3 business days of receipt. Delivery times may vary depending on the shipping method and destination. Please contact your local distributor for specific delivery times.
Synonyms
TESC antibody; CHP3Calcineurin B homologous protein 3 antibody; Tescalcin antibody; TSC antibody
Target Names
TESC
Uniprot No.
Target Background
Function
TESC antibody functions as an essential cofactor in maintaining cell pH balance. It regulates the activity of plasma membrane-type Na(+)/H(+) exchange by controlling the SLC9A1/NHE1 protein. TESC promotes the maturation, transport, cell surface stability, and exchange activity of SLC9A1/NHE1. It plays a crucial role in the differentiation of hematopoietic stem cells into megakaryocytes. TESC is essential for coupling ERK cascade activation with the expression of ETS family genes during megakaryocytic differentiation. It also contributes to granulocytic differentiation in an ERK-dependent manner. Additionally, TESC inhibits the phosphatase activity of calcineurin.
Gene References Into Functions
- This study revealed a significant interactive effect between the genotype of TESC at the rs7294919 locus and major depressive disorder (MDD) on hippocampal subfield volume. PMID: 28575645
- High Tescalcin expression is associated with colorectal cancer. PMID: 27485112
- CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy by inhibiting GSK3alpha/beta phosphorylation. PMID: 25935310
- This study demonstrated highly significant effects of rs7294919 of tescalcin on hippocampal gray matter volumes. PMID: 24776739
- TESC is a binding partner and regulator of subunit 4 of the COP9 signalosome. PMID: 24659803
- TESC is overexpressed in colorectal cancer. PMID: 24811141
- Loss of both N-myristoylation and calcium binding of CHP3 reduces cell surface stability of NHE1. PMID: 22984264
- Tescalcin is one of the key gene products involved in switching differentiation programs in certain cell types. PMID: 20060826
- CHP3 binds directly to the proximal juxtamembrane C-terminal region (amino acids 505-571) of rat NHE1, in the same region that binds CHP1 and CHP2. PMID: 18321853
Database Links
Protein Families
Calcineurin regulatory subunit family, CHP subfamily
Subcellular Location
Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane.
Tissue Specificity
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
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