TGFB2 Antibody

• Upregulation of miR-328 can further suppress the expression of TGF-beta2 and ECM proteins. In summary, this research demonstrated that miR-328 could prevent renal fibrogenesis by directly targeting TGF-beta2. These findings suggest that elevated renal miR-328 levels could represent a novel therapeutic strategy for treating renal fibrosis. PMID: 30160133
• Significantly, high expression levels of HIF-1alpha/TGF-beta2/GLI2 strongly correlated with patient relapse following chemotherapy, highlighting their potential as biomarkers and therapeutic targets for chemoresistance in colorectal cancer. PMID: 29891662
• These data suggest that miR-592 may exert its suppressive role in breast cancer, at least in part, by targeting TGFbeta-2, indicating that miR-592 could be a novel target for breast cancer treatment. PMID: 29039599
• MicroRNA-486-5p suppresses TGFB2-induced proliferation, invasion, and epithelial-mesenchymal transition of lens epithelial cells by targeting Smad2. PMID: 29229876
• Results show that TGF-beta2 is highly expressed in glioma and correlated with poor prognosis in glioma patients. Further findings reveal a potential mechanism of autophagy-associated glioma invasion where TGF-beta2 could initiate autophagy via Smad and non-Smad pathways to promote glioma cells' invasion. PMID: 29145888
• Up-regulation of TGF-beta2 demonstrated a strong association with muscle invasion in bladder cancer. PMID: 28261684
• This report describes early adaptive drug-escape in EGFR-mutant lung tumor cells that depends on TGFbeta2-bioenergetics-mitochondrial priming. PMID: 27852038
• Microarray analysis confirmed the expression of TGFB2 observed through RT-PCR. Ion transport could be affected promptly after ANP treatment, leading to the promotion of vein endothelial cell cytolysis, enhanced endothelial permeability, and subsequent activation of immune responses. PMID: 29279524
• A 4.7 Mb deletion encompassing TGFB2 is associated with features of Loeys-Dietz syndrome and osteoporosis. PMID: 28544325
• Results indicate that the interaction of matrix AGEs with RAGE plays a role in the TGFbeta2-mediated EMT of lens epithelial cells. This suggests that blocking RAGE could be a strategy to prevent PCO and other age-associated fibrosis. PMID: 27263094
• Data suggest that VEGF-mediated regulation of miR-30b in HUVEC is crucial for capillary morphogenesis, as increased miR-30b expression inhibits capillary morphogenesis through enhanced expression of TGFbeta2. PMID: 28977001
• Data suggest that TGFB2 (the most abundant growth factor in human milk) binding to Tgfb2r elicits robust/rapid responses in small intestinal mucosal cells, leading to stimulation of Egr1 transport to the nucleus and cell differentiation. More than 15 Wnt signaling pathway genes have Egr1 binding sites/response elements. Egr1 binds to the Axin1 promoter and functionally activates gene expression (Axin1 = axis inhibition protein 1). PMID: 27697743
• RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells. PMID: 28640846
• High TGFbeta2 expression is associated with oral cancer. PMID: 27803052
• TGF-beta2 is a new regulatory factor for KCC2 functional activation and membrane trafficking. PMID: 27505893
• Our data expand the phenotype of Loeys-Dietz syndrome type 4. We confirm that TGFb2 mutations are responsible for true Loeys-Dietz (LDS) syndrome with non-specific features of connective tissue disorders and diffuse vascular lesions. PMID: 27440102
• TGF-beta signaling regulated cell growth of cancer-associated fibroblasts. PMID: 27880067
• Localized constitutive expression and release of TGF-beta2 by TM cells may promote or exacerbate elevation of IOP in POAG. PMID: 26743044
• Advanced glycation endproducts in the lens capsule promote the TGFbeta2-mediated fibrosis of lens epithelial cells. PMID: 26853893
• Our study suggests that lnc-ATB promotes tumor progression by interacting with miR-141-3p, indicating that Lnc-ATB may be a valuable prognostic predictor for GC. In conclusion, the positive feedback loop of lnc-ATB/miR-141-3p/TGF-beta2 may be a potential therapeutic target for the treatment of GC. PMID: 28115163
• Decorin can alter the bioactivity of TGF-beta2 on human myoblast migration. PMID: 27644884
• Findings indicate that lncRNA-ATB governs the autocrine secretion of TGF-beta2 in KFs, at least in part, by downregulating the expression level of ZNF217 via miR-200c, suggesting a signaling axis consisting of lncRNA-ATB/miR-200c/ZNF217/TGF-beta2. PMID: 27090737
• Association between SNP rs6658835 in TGF-beta2 and conotruncal heart defects. PMID: 27564654
• miR-422a directly targeted TGFbeta2 and regulated its expression and the activation of downstream molecules, smad2 and smad3, in osteosarcoma cells. PMID: 27779704
• miR-378a expression is associated with its methylation status in TGF-beta1-treated cells, and epigenetically-regulated miR-378a inhibits TGF-beta1-induced hepatic stellate cells activation, at least in part, via TGF-beta2. PMID: 27855367
• We detected and verified a list of differentially expressed microRNAs in PE placentas by HTS and qRT-PCR, and provided preliminary evidence for the role of miR-193b-3p in the pathogenesis of preeclampsia by targeting TGF-beta2. PMID: 26822621
• Likely pathogenic variants included a TGFB2 variant in one patient and a SMAD3 variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK and MFAP5, which were identified in a third patient. PMID: 26854089
• Results provide evidence that miR-148a decreases the expression of TGFbeta2 and SMAD2 in gastric cancer cells through binding to their 3'UTRs. PMID: 26983401
• TGF-beta2 induces epithelial-mesenchymal transition by activating the PI3K/Akt/mTOR signaling pathway in cultured human lens epithelial cells. PMID: 26647778
• Human retinal pigment epithelial cells were cultured in the presence or absence of TGF-beta2, and reverse-transcription quantitative PCR was performed to determine the mRNA expression of IDO and Nrf2. PMID: 26676103
• TGF-beta2 induces Grb2 to recruit PI3-K to TGF-RII, which activates JNK/AP-1-signaling and augments the invasiveness of Theileria-transformed macrophages. PMID: 26511382
• In conclusion, each of the DPP-4 inhibitors may have unique drug-specific effects. PMID: 26826382
• Active CREB1 promotes a malignant TGFbeta2 autocrine loop in glioblastoma. PMID: 25084773
• Comparison of the aqueous humor TGF-beta2 level between patients with open-angle glaucoma (OAG) and controls provides direct evidence for the role of TGF-beta2 in the etiology of OAG. (meta-analysis) PMID: 26019480
• There is a borderline significant association between higher mean TGF-beta2 levels in breast milk and more severe pathologic diagnoses. PMID: 25604865
• These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2, indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in renal cell carcinoma. PMID: 25813153
• TGFbeta2 is a key growth promoter of CD44(hi) cells that survived chemotherapy and also is a growth inhibitor of cells that survived hypoxia. PMID: 26340918
• MicroRNA-153 inhibits osteosarcoma cells proliferation and invasion by targeting TGF-beta2. PMID: 25793604
• High expression of TGFB2 is associated with melanoma. PMID: 25743834
• Data suggest that the intrinsic transforming growth factor beta 2-triggered stromal cell-derived factor-1-C-X-C chemokine receptor-4 signaling is crucial for drug resistance in bone marrow (BM)-slow-cycling disseminated tumor cells (DTCs). PMID: 25504440
• Here, we show that increased TGF-beta2 signaling through ALK5 plays a role in hypoxia-induced redifferentiation of chondrocytes. PMID: 25621374
• TGF-beta2 secretion from retinal pigmented epithelium decreases with polarization and becomes apically oriented. PMID: 25496702
• Glycated collagen in the cardiac interstitium triggers an autocrine TGF-beta2 signaling pathway that stimulates alpha11 integrin expression through Smad2/3 binding elements in the alpha11 integrin promoter. PMID: 24962729
• These results revealed no correlation between the normalized expression of TGF-beta2, TGF-betaRI, or TGF-betaRII and EDSS scores. PMID: 26037400
• These data shed light on previously unrecognized roles of Mkx in tendinopathy, tenogenesis, and tendon repair, as well as in regulating the TGFbeta pathway. PMID: 25332192
• High levels of furin, TNF-alpha, and TGF-beta2 may be the reason for proceeding decidualization, placentation, and prevention from abortion, despite terminating the fetal life. PMID: 26065233
• TGF-beta2 therefore promotes the adhesion and invasiveness of virulent macrophages by modulating COX2, EP4, and PKIG transcription to initiate a prostaglandin E2 (PGE2)-driven autostimulatory loop that augments PKA and EPAC activities. PMID: 25690101
• TGF-beta2 induced MYOC expression and secretion in human primary cultured trabecular meshwork cells. PMID: 25197353
• Data indicate that TGF-beta2 (TGFB2) and TGF beta type III receptor (TGFBR3) are target genes of miR-193b in chondrogenesis. PMID: 25728278
• ALDH1 and TGFbeta2 play important roles in the development of breast cancer. PMID: 25120797

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HGNC: 11768

OMIM: 190220

KEGG: hsa:7042

UniGene: Hs.133379