tin-10 Antibody
Description
Overview
TIN-Ag is a 48–58 kDa glycoprotein belonging to the peptidase C1 family. It is secreted by renal tubule epithelium and small intestine columnar epithelium. It plays a critical role in renal tubule basement membrane (BM) organization, laminin polymerization inhibition, and integrin receptor binding (α3β1, αvβ3) .
Functional Insights
| Function | Mechanism |
|---|---|
| BM organization | Promotes matrix assembly and epithelial adhesion |
| Integrin binding | Mediates epithelial-mesenchymal transition regulation |
| Species homology | 86% aa identity with mouse proTIN-Ag (aa 20–476) |
Associated Antibody
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Human TIN-Ag Antibody AF6797 (R&D Systems):
Overview
Septin-10 is a cytoskeletal GTPase involved in cytokinesis, vesicle trafficking, and actin filament organization. It localizes to the nucleus and cytoplasm, with roles in cellular division and structural integrity .
Comparative Analysis
| Feature | TIN-Ag Antibody | Septin-10 Antibody |
|---|---|---|
| Target Class | Peptidase C1 glycoprotein | Cytoskeletal GTPase |
| Molecular Weight | 48–58 kDa | Predicted ~50 kDa (varies by isoform) |
| Primary Function | Renal BM organization | Cytokinesis, actin dynamics |
| Therapeutic Relevance | Limited (research focus on kidney diseases) | Under investigation for cancer and cell division disorders |
Research and Clinical Context
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TIN-Ag: Linked to tubulointerstitial nephritis and epithelial-mesenchymal transition pathologies .
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Septin-10: Implicated in tumorigenesis and neurodegenerative diseases due to cytoskeletal dysregulation .
Data Sources and Repositories
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
