TLE3 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid repeated freeze-thaw cycles.
Lead Time
Typically, we can ship products within 1-3 business days of receiving your order. Delivery times may vary depending on your location and the chosen shipping method. Please contact your local distributor for specific delivery details.
Synonyms
E(sp1) homolog Drosophila antibody; Enhancer of split groucho 3 antibody; Enhancer of split groucho-like protein 3 antibody; ESG 3 antibody; ESG antibody; ESG3 antibody; FLJ39460 antibody; GRG 3 antibody; GRG3 antibody; HsT18976 antibody; KIAA1547 antibody; TLE 3 antibody; Tle3 antibody; TLE3_HUMAN antibody; Transducin like enhancer of split 3 antibody; Transducin like enhancer of split 3 homolog of Drosophila E(sp1) antibody; Transducin like enhancer protein 3 antibody; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) antibody; Transducin-like enhancer protein 3 antibody
Target Names
TLE3
Uniprot No.
Target Background
Function
TLE3 is a transcriptional corepressor that interacts with various transcription factors. It plays a role in inhibiting transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The activity of full-length TLE family members can be modulated by association with dominant-negative AES.
Gene References Into Functions
- Patients with TLE3-negative tumors exhibited poorer progression-free survival outcomes compared to patients with TLE3-positive tumors when analyzing prognosis within the triple-negative breast cancer (TNBC) group. However, no significant difference in prognosis was observed between TLE3-positive and negative patients when considering all patients. PMID: 28859615
- The Wnt signaling pathway inactivates the TLE3 co-repressor through ubiquitination by the HECT E3 ubiquitin ligase Hyd/UBR5. PMID: 28689657
- MicroRNA miR-744 activates the Wnt/beta-catenin pathway by targeting multiple negative regulators, including SFRP1, GSK3beta, TLE3, and NKD1. Notably, NKD1 is a primary functional target of miR-744. PMID: 28107193
- Increased adipose tissue (AT) TLE3 levels observed in individuals with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role in enhancing AT function under reduced PPARgamma expression. PMID: 25249007
- The induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation. PMID: 24444608
- High TLE3 expression is associated with favorable responses to taxane-containing chemotherapy regimens in ovarian carcinoma. PMID: 22194527
- The absence of TLE3 expression in cutaneous angiosarcoma may reflect differing pathogenesis. PMID: 22050093
- Findings suggest that various isoforms of TLE genes are commonly transcribed in human tissues, indicating a potential role for TLE3 in prostate cancer development. PMID: 18273443
Database Links
Protein Families
WD repeat Groucho/TLE family
Subcellular Location
Nucleus.
Tissue Specificity
Placenta and lung.
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