tlk-1 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
tlk-1 antibody; C07A9.3 antibody; Serine/threonine-protein kinase tousled-like 1 antibody; EC 2.7.11.1 antibody; Tousled-like kinase 1 antibody
Target Names
tlk-1
Uniprot No.
Target Background
Function
This antibody targets a protein essential for proper transcription during embryonic development. It is believed to function during transcription elongation by activating the RNA polymerase II large subunit (ama-1) through phosphorylation of Ser-2 residues within the C-terminal domain's 7-residue repeats. Importantly, it does not phosphorylate histone H3.
Gene References Into Functions
TLK-1's functions extend beyond transcription:
1. **Chromosome Condensation and Segregation:** TLK-1 contributes to these processes. Furthermore, it plays a role in cytokinesis by localizing AIR-2 to midzone microtubules. [PMID: 20705056](https://www.ncbi.nlm.nih.gov/pubmed/20705056)
2. **Chromosome Segregation and Aurora B Kinase Regulation:** TLK-1 functions as both a substrate and regulator of the Aurora B kinase AIR-2, contributing to accurate chromosome segregation. [PMID: 15916946](https://www.ncbi.nlm.nih.gov/pubmed/15916946)
Database Links
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Subcellular Location
Nucleus.
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