TLR13 Antibody
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In Stock 
Product Specs
Buffer
PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% glycerol.
Form
Liquid
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your orders. Delivery times may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery timelines.
Synonyms
Tlr13 antibody; Toll-like receptor 13 antibody; EC 3.2.2.6 antibody
Target Names
Tlr13
Uniprot No.
Target Background
Function
TLR13 (Toll-like receptor 13) is a component of both innate and adaptive immunity. It recognizes and binds to 23S rRNA from bacteria. TLRs play a crucial role in regulating the host's immune response against pathogens by recognizing molecular patterns specific to microorganisms. TLR13 operates through the MYD88 and TRAF6 pathways, leading to NF-κB activation, cytokine secretion, and the subsequent inflammatory response. TLR13 specifically binds to the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also targeted by MLS group antibiotics (including erythromycin). There is evidence suggesting TLR13 may also recognize vesicular stomatitis virus; however, further research is needed to confirm this observation.
Gene References Into Functions
- The structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA has been elucidated. PMID: 26676765
- S. pyogenes is initially recognized in a phagocytosis-independent manner by TLR2 and subsequently by TLR13 upon internalization. PMID: 25756897
- TLR13 expressed by immune cells detects bacterial RNA with remarkable sequence specificity. PMID: 23110254
- These findings support the involvement of TLR13 in the recognition of group B streptococcus, although blocking this receptor's function can be compensated for by other endosomal toll-like receptors. PMID: 25225249
- TLR13 activation contributes to the innate response against Gram-positive bacteria, establishing TLR13 as a receptor for bacterial RNA. PMID: 22896636
- These results demonstrate that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that serves as the binding site for macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably, PMID: 22821982
- Investigating the potential role of the novel Toll-like receptor tlr13 in the recognition of viral infection. PMID: 21131352
- These findings elucidate the mechanism of Tlr13 gene regulation, providing insights into Tlr13's function in the immune response to pathogens. PMID: 19487701
Database Links
Protein Families
Toll-like receptor family
Subcellular Location
Endosome membrane; Single-pass type I membrane protein.
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