TM4SF1 Recombinant Monoclonal Antibody
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Description
Mechanisms of Action
These antibodies exert anti-tumor effects through multiple pathways:
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Angiogenesis Inhibition: Block VEGF-A-induced endothelial cell migration and filopodia formation, disrupting tumor blood vessel maturation .
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Cell Cycle Arrest: Prevent cytokinesis and induce endothelial cell senescence .
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Immune Activation: In CAR-T therapies, TM4SF1-targeted antibodies trigger IFN-γ and TNF-α release, enhancing cytotoxicity against tumor cells .
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Internalization: Antibodies like 8G4 are internalized into tumor cells, reaching nuclear compartments to induce apoptosis (Fig. 5C–5F) .
Preclinical Efficacy Data
Key findings from in vitro and in vivo studies:
Clinical Development Status
Four TM4SF1-targeted therapies are under investigation:
Phase I trials report excellent tolerance and complete remission in some patients .
Research Applications
Validated uses in experimental settings:
Challenges and Future Directions
While TM4SF1 antibodies show therapeutic promise, limitations include:
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Unclear mechanisms underlying chemosensitization effects in pancreatic cancer
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Need for Phase II/III trials to validate safety and efficacy
Current research focuses on optimizing antibody-drug conjugates (ADCs) and combination therapies with VEGF inhibitors .
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery time may vary depending on the purchase method and location. Please consult your local distributors for specific delivery timelines.
Synonyms
TM4SF1 Recombinant Monoclonal Antibody
Target Names
Uniprot No.
Target Background
Gene References Into Functions
TM4SF1 Gene References
- Our research identifies a novel regulatory pathway involving TM4SF1, DDR1, MMP2, and MMP9 that promotes the formation and function of invadopodia, supporting cell migration and invasion in pancreatic cancer. PMID: 28368050
- Regulation of transmembrane-4-L-six-family-1 (TM4SF1) in bladder cancer cells can be induced by the peroxisome proliferator-activated receptor gamma (PPARgamma)-sirtuin 1 (SIRT1) feedback loop. PMID: 29175458
- TM4SF1 has been identified as a direct target for miR-520f in hepatocellular carcinoma (HCC) cells, where its expression is upregulated and inversely correlated with that of mir-520f. PMID: 29505836
- Findings suggest that miR-30a plays a crucial role in regulating TM4SF1, VEGF, and E-cadherin, contributing to CRC lymph node metastasis, making it a potential new therapeutic target for CRC. PMID: 28528497
- High TM4SF1 expression is correlated with esophageal cancer. PMID: 27974706
- Replacing the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 led to increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels. PMID: 28129652
- Results indicate that the expression of transmembrane 4 L6 family member 1 (TM4SF1) is higher in pancreatic cancer tissues and pancreatic cancer cell lines compared to controls. PMID: 27459514
- Studies demonstrate that TM4SF1 expression is elevated in colorectal cancer (CRC) and associated with tumor stage and lymph node metastasis. Additionally, miR-9 directly targets its binding site in the TM4SF1 3'-UTR, playing a critical role in regulating CRC cell migration and invasion. Furthermore, miR-9 regulates cell motility by suppressing PMID: 26983891
- Findings suggest that TM4SF1 is a surface membrane antigen highly expressed in pancreatic cancer cells, leading to increased chemoresistance to gemcitabine. TM4SF1 may be a promising target to overcome the chemoresistance of pancreatic cancer. PMID: 26709920
- TM4SF1 overexpression significantly contributes to MDA-MB-231 cell migration while decreasing apoptotic cells. PMID: 26464650
- Research indicates that TM4SF1 expression is associated with a better prognosis in pancreatic cancer. Its loss contributes to the invasion and migration of pancreatic cancer cells. PMID: 26035794
- We observed that miR-203 was significantly downregulated in OSF tissues compared to normal buccal mucosa tissues, and that miR-203 negatively regulated secreted SFRP4 and positively regulated TM4SF1. PMID: 25872484
- Transmembrane-4-L-six-family-1 is overexpressed in human gliomas in general, and the precise level of expression might predict outcome and could be clinically valuable. PMID: 25855954
- These findings validate TM4SF1 as a promising candidate for cancer therapy with antibody-bound toxins that can react with either cytoplasmic or nuclear targets in tumor cells or tumor-associated vascular endothelium. PMID: 26241677
- TM4SF1 is a small plasma membrane glycoprotein that regulates cell motility and proliferation, and potentially serves as a new vascular therapeutic target in cancer. PMID: 24986520
- High TM4SF1 expression is associated with pancreatic cancer. PMID: 24285464
- TM4SF1, similar to genuine tetraspanins, acts as a molecular organizer that interacts with membrane and cytoskeleton-associated proteins and uniquely initiates the formation of nanopodia, facilitating cell polarization and migration. PMID: 21626280
- We provide evidence that ARHGDIA, COBLL1, and TM4SF1 are negative regulators of apoptosis in cultured tumor cells. PMID: 21569526
- Inhibition of cell migration following targeted knockdown of TM4SF1 protein expression suggests its role in prostate cancer cell metastasis. PMID: 21656834
- TM4SF1 can serve as a surface protein marker that uniquely identifies MSCs from diverse cell sources, particularly fibroblast-rich connective tissues. PMID: 20486778
- TAL6 may play a role in cancer invasion and metastasis. PMID: 12855661
- These data suggest that L6-Ag influences cell motility via TERM by regulating the surface presentation and endocytosis of some of their components. PMID: 18270265
- The gene ratio test with the TM4SF1 gene for survival of patients with malignant pleural mesothelioma has robust predictive value. PMID: 19401544
Database Links
Protein Families
L6 tetraspanin family
Subcellular Location
Membrane; Multi-pass membrane protein.
Tissue Specificity
Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.
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