TMED5 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
CGI 100 antibody; DKFZp781B2248 antibody; p24 family protein gamma-2 antibody; p24gamma2 antibody; p28 antibody; RP5 976O13.2 antibody; TMED 5 antibody; TMED5 antibody; TMED5_HUMAN antibody; Transmembrane emp24 domain containing protein 5 antibody; Transmembrane emp24 domain-containing protein 5 antibody; Transmembrane emp24 protein transport domain containing 5 antibody; UNQ397/PRO733 antibody
Target Names
Uniprot No.
Target Background
Function
TMED5 plays a crucial role in vesicular protein trafficking, primarily within the early secretory pathway. It is essential for maintaining Golgi apparatus integrity and participates in protein exchange between Golgi stacks during their assembly. Evidence suggests it is not required for COPI-vesicle-mediated retrograde transport.
Gene References Into Functions
- The luminal alpha-helical domain, but not the GOLD domain, of p24γ2 (a TMED family member) was found necessary for efficient GPI-AP transport. (PMID: 24778190)
- Studies have shown a dose- and time-dependent decrease in cgi-100 (a TMED5 homolog) mRNA expression in K562 cells treated with matrine. Conversely, cgi-100 overexpression increased K562 cell proliferation and immaturity. (PMID: 18549622)
Database Links
Protein Families
EMP24/GP25L family
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Probably cycles between compartments of the early secretatory pathway.
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