TMEM168 Antibody

What Is TMEM168 Antibody?

TMEM168 antibody is a polyclonal or monoclonal immunoglobulin targeting the TMEM168 protein, which belongs to the transmembrane protein family. This protein is localized on the cell membrane and has been associated with diseases such as glioblastoma multiforme (GBM) and psychiatric disorders . The antibody is widely used in techniques like Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to investigate TMEM168's expression and function .

Key Applications of TMEM168 Antibody

The antibody is utilized in diverse experimental workflows:

Role in Glioblastoma:

• Overexpression in GBM: TMEM168 mRNA and protein levels are elevated in GBM patients, correlating with shorter survival (median survival: 8.76 months vs. 13.92 months in low-expression groups) .

• Knockdown Effects: siRNA-mediated TMEM168 silencing in U87 and U373 cells reduced proliferation by 15–46%, induced G0/G1 cell cycle arrest, and promoted apoptosis via suppression of Wnt/β-catenin targets (β-catenin, C-myc, cyclin D1, survivin) .

• Mechanistic Insights: TMEM168 antibody confirmed reduced β-catenin pathway activity in treated cells, supporting its role as a therapeutic target .

Table: Key Findings From TMEM168 Studies

Future Directions

Current research highlights TMEM168 as a biomarker for GBM progression and a potential drug target. Further studies using TMEM168 antibodies could explore its interactions with ion channels or its role in psychiatric disorders . Standardization of antibody validation across laboratories remains critical for reproducibility .