TMOD1 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid repeated freeze-thaw cycles.
Lead Time
Product dispatch typically occurs within 1-3 business days of order receipt. Delivery times may vary depending on the order fulfillment method and destination. Please contact your local distributor for precise delivery estimates.
Synonyms
D9S57E antibody; E Tmod antibody; E tropomodulin antibody; E-Tmod antibody; Erythrocyte tropomodulin antibody; ETMOD antibody; MGC124125 antibody; MGC124126 antibody; OTTHUMP00000021743 antibody; TMOD antibody; Tmod1 antibody; TMOD1 protein antibody; TMOD1_HUMAN antibody; Tropomodulin 1 antibody; Tropomodulin-1 antibody
Target Names
TMOD1
Uniprot No.
Target Background
Function
This antibody targets TMOD1, a protein that inhibits both elongation and depolymerization of actin filaments at their pointed ends. The Tmod/tropomyosin (TM) complex contributes to the formation of short actin protofilaments, influencing the structure of the membrane cytoskeleton. TMOD1 may play a significant role in regulating actin filament organization through preferential binding to specific tropomyosin isoforms at their N-termini.
Gene References Into Functions
TMOD1 Function: Relevant Research Highlights
- Erythroblast Function: Investigations into Tmod1's role in mouse and human erythroblasts. PMID: 28729432
- Cardiomyopathy: A mutation was found to reduce binding affinity for Lmod2 and Tmod1, providing a molecular basis for familial dilated cardiomyopathies. PMID: 26873245
- Triple-Negative Breast Cancer (TNBC): A study revealed a novel TMOD1-mediated link between NF-κB activation and MMP13 induction, contributing to the malignant phenotype of TNBC. PMID: 25398440
- Tropomyosin Binding: Tmod1 and Tmod3 exhibit distinct tropomyosin-binding site utilization patterns. PMID: 24922351
- Structural Analysis: Structural and biochemical analyses indicate that a single Tmod molecule interacts with three actin subunits at the pointed end, also contacting two tropomyosin molecules on each side of the filament. PMID: 25061212
- Tropomyosin Interaction: Tropomyosin requires an intact N-terminal coiled coil for interaction with TMOD1. PMID: 11964245
- Cancer Cell Expression: Reduced TM1, TM2, and TM3 levels in human transitional cell carcinoma cells are significantly upregulated by mitogen-activated protein kinase pathway inhibition. PMID: 15095301
- TMOD1 Dimerization: The N-terminal “KRK ring” may balance electrostatic and hydrophobic interactions in TMOD1 dimerization and its binding to tropomyosin. PMID: 16297372
- TMOD1-TM5 Interaction: Identification of key amino acid residues on Tmod-1 crucial for its interaction with TM5 (a non-muscle tropomyosin isoform). PMID: 16434395
Database Links
Protein Families
Tropomodulin family
Subcellular Location
Cytoplasm, cytoskeleton.
Tissue Specificity
Highly expressed in the erythrocyte, heart and skeletal muscle.
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
