TNIK Antibody, FITC conjugated
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
We typically dispatch products within 1-3 working days after receiving your order. Delivery times may vary depending on the purchasing method or location. Please consult your local distributor for specific delivery timelines.
Synonyms
EC 2.7.11.1 antibody; KIAA0551 antibody; Tnik antibody; TNIK_HUMAN antibody; Traf2 and NCK interacting kinase antibody; Traf2 and NCK-interacting protein kinase antibody
Target Names
Uniprot No.
Target Background
Function
TNIK (Traf2- and Nck-interacting kinase) is a serine/threonine kinase that plays a pivotal role as an activator of the Wnt signaling pathway. It is recruited to promoters of Wnt target genes and is essential for activating their expression. TNIK is thought to mediate this activation by phosphorylating TCF4/TCF7L2. Additionally, it appears to function upstream of the JUN N-terminal pathway. TNIK may be involved in the cellular response to environmental stress. It is part of a signaling complex composed of NEDD4, RAP2A, and TNIK that regulates neuronal dendrite extension and arborization during development. More broadly, TNIK may participate in cytoskeletal rearrangements and regulate cell spreading. It also phosphorylates SMAD1 on Thr-322.
Gene References Into Functions
- TNIK is essential for the tumor-initiating function of colorectal cancer stem cells. Inhibition of TNIK is considered a promising therapeutic strategy. PMID: 27562646
- Research suggests that TNIK is involved in the interleukin-6-dependent proliferation of multiple myeloma cells. PMID: 28467797
- Findings indicate that TNIK may be involved in the proliferation of multiple myeloma IM-9 cells and in the anti-cancer activity of dovitinib through inhibition of the endogenous Wnt signaling pathway. PMID: 26995282
- Exome sequencing revealed a homozygous truncating mutation in TNIK, leading to complete loss of the protein, in individuals from multiple families. TNIK's established role in dendrite development and synaptic transmission suggests that the phenotype observed in these patients aligns with the previously reported Tnik (-/-) phenotype in a murine model. PMID: 27106596
- A genome-wide association study identified three novel susceptible loci associated with adolescent idiopathic scoliosis, including rs7593846 near MEIS1, rs7633294 near MAGI1, and rs9810566 near TNIK. PMID: 28334814
- Results suggest that TNIK plays a crucial role in pancreatic carcinogenesis and may be a novel therapeutic target for pancreatic cancer. PMID: 26269113
- High TNIK expression in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients. PMID: 26499327
- Endogenous substrates of TNIK have been identified in neurons, along with consensus sequences for TNIK. PMID: 26645429
- Nuclear p-TNIK expression was studied in hepatocellular carcinoma, and its association with poor prognosis suggests it may be a candidate prognostic marker for this type of cancer. PMID: 25160513
- Dynamic changes in TNIK offer a mechanism for protecting cells from external stimuli. PMID: 23355318
- TNIK is critical for the proliferation and survival of EBV-transformed B-cells. PMID: 22904686
- TNIK is essential for the activation of both the canonical Wnt pathway and the JNK pathway, and it acts as a pro-survival factor. PMID: 21710359
- TNIK serves as a specific effector of Rap2, regulating the actin cytoskeleton. PMID: 15342639
Database Links
Involvement In Disease
Mental retardation, autosomal recessive 54 (MRT54)
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular Location
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Tissue Specificity
Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
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