TNIP1 Antibody

1. This review explores TNIP1's role in autoimmune diseases as a regulator of Toll-like receptor signaling. PMID: 30402506
2. Research demonstrates that ABIN1 acts as a modulator to down-regulate HDAC1 ubiquitination via three distinct sites, thereby stabilizing HDAC1 by inhibiting its lysosomal and proteasomal degradation. PMID: 29058807
3. Findings suggest that TNIP1 SNP (rs7708392) might be associated with the development of lupus nephritis in Egyptian SLE patients. PMID: 29589214
4. Cell viability and apoptosis in the hepatic cell line L02 were assessed after hypoxia/reoxygenation (H/R) treatment. MTT assay revealed that cell viability was inhibited after H/R treatment but reversed after TNIP1 transfection. PMID: 29709475
5. The association of TNIP1 was stronger in AIH without HLA-DRB1*04:05 allele (P = 0.0063, Q = 0.0127, OR 1.48, 95% CI: 1.12-1.96), although the association was not detected in AIH with DRB1*04:05. PMID: 29559739
6. Naf1 contributes to the maintenance of HIV-1 latency by inhibiting long terminal repeat driven HIV-1 gene transcription in a nuclear factor kappa B-dependent manner. PMID: 27795436
7. The risk allele for the TNIP1 rs7708392 polymorphism was associated with systemic lupus erythematosus susceptibility. PMID: 29783072
8. C/EBP beta LAP isoform expression was increased, and LIP/TNFAIP3/TNIP1 expression was decreased in systemic lupus erythematosus (SLE) patients. LAP expression was positively correlated with SLE disease activity; TNFAIP3 and TNIP1 expression was negatively correlated with SLE disease activity. PMID: 27659348
9. Genetic variation in the TNIP1 gene is associated with gastric carcinoma. PMID: 27250029
10. A cross-ethnic meta-analysis identified an association of the GPX3-TNIP1 locus with ALS. [Meta-Analysis] PMID: 28931804
11. These studies define a novel role for ABIN1 dysfunction and NF-κB in mediating glomerulonephritis through proinflammatory activation of podocytes. PMID: 28935578
12. IM could upregulate A20 protein to inhibit the activation of the NF-κB pathway in Jurkat T cells, independent of the ABIN1 protein. PMID: 28502291
13. LILRB1 ligation during monocyte differentiation to dendritic cells in vitro increases ABIN1 expression. Increased ABIN1 expression occurs in "immunosuppressive" monocytes of patients with non-Hodgkin lymphoma ex vivo. ABIN1 siRNA allows dendritic cells and immunosuppressive monocytes to respond to stimulation by allowing NF-κB translocation to the nucleus, increased phagocytosis, cytokine secretion, and T-cell stimulation. PMID: 27129285
14. These findings highlight ABIN1 as an intrinsic suppressor of HIV-1 mRNA transcription by regulating the ubiquitination of Tat. PMID: 28193275
15. Polymorphisms in TNIP1 are associated with GPP in the Chinese Han population. However, no association with PPP was found. These findings suggest that TNIP1 might be a susceptibility gene for GPP. PMID: 27364786
16. The findings of this study suggest that TNIP1 is a new potential predisposing gene to spina bifida (SB), and its pathway needs to be investigated in human NTD to confirm its role and plan appropriate counseling for families. PMID: 27125519
17. Data suggest that reduced TNFalpha-induced protein 3-interacting protein 1 (TNIP1) expression may play a role in the pathogenesis of myasthenia gravis (MG) for patients with thymoma. PMID: 27577206
18. HIV-1 relies on host-cell-encoded factors to complete its life cycle. Data suggest that nucleus-located NAF1/TNIP1 promotes nuclear export of un-spliced HIV-1 gag mRNA. The association between NAF1/TNIP1 and CRM1 is required for this function. PMID: 26733199
19. Hepatitis C virus antigen stimulation up-regulates A20/A20-binding inhibitor of NF-κB binding protein expression, which subsequently contributes to inefficient M1 macrophage polarization. PMID: 26382585
20. Data suggest that tumor necrosis factor alpha-induced protein 3 (TNFAIP3) and TNFAIP3-interacting protein 1 (TNIP1) single nucleotide polymorphisms (SNPs) confer an increased risk of psoriasis in ethnic South Indian Tamils. PMID: 26738398
21. Given that TNIP1 may facilitate the function of TNFAIP3 in the negative feedback regulation of NF-κB activation, the corresponding transcript levels of TNIP1 in psoriasis vulgaris were investigated in this study. PMID: 25631139
22. This study aimed to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2, and COG6 genes were genetic risk factors for psoriasis in the Chinese population. PMID: 25264125
23. Single-nucleotide polymorphisms rs7708392 and rs495881 in TNIP1 were significantly associated with Lupus Nephritis in individuals with European or African ancestry. PMID: 25034154
24. HSPA6 regulation by TNIP1 occurs in promoter regions lacking binding sites for known TNIP1-repressed transcription factors. PMID: 25447897
25. This report details the role of TNIP1 genetic variants in conferring the risk of systemic lupus erythematosus in the Chinese population. PMID: 24091983
26. TNIP1 polymorphism may be a risk factor for VKH syndrome in Han Chinese. PMID: 24788730
27. Analysis of SNPs in the TNIP1 gene and expression of this gene in peripheral blood lymphocytes indicated that these SNPs were associated with the occurrence of systemic lupus erythematosus in Han Chinese patients. PMID: 23858047
28. We conclude that polymorphisms in TNIP1 are associated with antibody-positive primary Sjogren's syndrome. PMID: 23944604
29. Variants in the TNIP1 gene are associated with the risk for lupus nephritis and could be mechanistically involved in disease development via aberrant regulation of NF-κB and mitogen-activated protein kinase activity. PMID: 23970121
30. TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking and alcohol intake affect the risk of psoriasis. PMID: 23541940
31. Data indicate significant multiplicative interaction observed between NFKB1 rs28362491 and TNIP1 rs3792783 in systemic lupus erythematosus. PMID: 23911423
32. Analysis of the TNIP1 promoter reveals multiple transcription start sites in its GC-rich proximal regions along with two transcriptionally active specificity protein (SP) sites, responsive to both Sp1 and Sp3. PMID: 23464785
33. These data confirmed the influence of TNIP1 on an increased susceptibility to systemic sclerosis and reinforced this locus as a common autoimmunity risk factor. PMID: 22896740
34. This study demonstrated that the (151) Pro-->Ala change in TNIP1 is associated with myasthenia gravis. PMID: 23055271
35. Our results confirm the association signals between systemic lupus erythematosus and TNIP1 variants in multiple populations and provide new insight into the mechanism by which TNIP1 variants may contribute to SLE pathogenesis. PMID: 22833143
36. Data indicate that TNFAIP3, ETS1, and TNIP1 are probably common susceptibility genes for systemic lupus erythematosus (SLE) in Chinese populations, and they may contribute to the pathogenesis of multiple SLE subphenotypes. PMID: 22087647
37. This review integrates the current knowledge of TNIP1's functions with the diseases in which it has been associated to potentially elucidate the role this regulator has in promoting or alleviating these inflammatory diseases. PMID: 22542476
38. The TNIP1 distal promoter, approximately 4600 nucleotides upstream of a frequently utilized transcription start site region, contains PPAR-γ and NF-κB sites that bind the respective transcription factors in vivo. PMID: 22001530
39. Recombinant transgene facilitates the transcription of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis. PMID: 22093807
40. A markedly reduced expression of the TNIP1 gene and also its protein product were observed both in lesional skin tissue and in cultured dermal fibroblasts from SSc (Systemic sclerosis) patients. PMID: 21750679
41. The requirements for TNIP1-peroxisome proliferator activated receptor (PPAR) interaction are characteristic for coactivators; however, TNIP1 partially decreases PPAR activity. PMID: 21967852
42. The varying levels and distribution of TNIP1 in normal and disease state tissues could be expected to affect processes in which TNIP1 is involved. PMID: 22147607
43. The researchers found a genotype association of SNP rs1808593 NOS3 polymorphisms and HIE. PMID: 21674837
44. ABIN1 requires its ubiquitin binding domain and cooperates with TAX1BP1 and A20 to restrict antiviral signaling. PMID: 21885437
45. The IL23A and TNIP1 genes showed convincing evidence for association SNPs mapping to previously reported psoriasis loci show evidence for association to PSA. PMID: 21623003
46. The interaction of ABIN1 with polyubiquitin is required to limit the activation of TLR-MyD88 pathways and prevent autoimmunity. PMID: 21606507
47. A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma. PMID: 21266526
48. Association of TNIP1 with systemic lupus erythematosus was confirmed in a Japanese population. PMID: 20849588
49. Significant associations were found for the single nucleotide polymorphism rs10036748 of TNIP1 with photosensitivity and vasculitis in patients with systemic lupus erythematosus. PMID: 20516000
50. A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling. PMID: 12220502

Show More

Hide All

HGNC: 16903

OMIM: 607714

KEGG: hsa:10318

STRING: 9606.ENSP00000317891

UniGene: Hs.355141