TOB1 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Generally, we can ship your orders within 1-3 business days of receipt. Delivery times may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery times.
Synonyms
TOB1 antibody; TOB antibody; TROB1 antibody; Protein Tob1 antibody; Transducer of erbB-2 1 antibody
Target Names
TOB1
Uniprot No.
Target Background
Function
TOB1 is an anti-proliferative protein. Its function is mediated by association with deadenylase subunits of the CCR4-NOT complex. TOB1 facilitates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7, which leads to target mRNA deadenylation and decay.
Gene References Into Functions
- MiR-590 targets TOB1, which is significantly decreased in patients with multiple sclerosis. PMID: 28947212
- The dual-luciferase reporter assay confirmed that miR-25 harboring the A allele caused an incapacitation of binding at the TOB1. In conclusion, rs41274221 in miR-25 is a subgroup that may protect patients from further growth and metastasis of gastric cancer and might serve as a novel biomarker for the disease. PMID: 26572149
- TOB1 plays a novel role in mediating the survival of estrogen-independent breast cancers. PMID: 26165839
- Reduced TOB1 expression in gastric adenocarcinoma is associated with the extent of differentiation and the TNM stage of gastric cancer. PMID: 25760308
- MiR-25 promotes GC progression by directly downregulating TOB1 expression and may be a noninvasive biomarker for the prognosis of GC patients. PMID: 25043310
- Arsenite-induced oxidative stress inhibits deadenylation of mRNA primarily through downregulation of Tob and Pan3, both of which mediate the recruitment of deadenylases to mRNA. PMID: 25446091
- Tob is a key factor in the regulation of c-myc gene expression, which is essential for cell growth. PMID: 23178487
- TOB1 demonstrated a radioprotective function in the immortalized normal human bronchial epithelial cell line. PMID: 23756562
- TOB1 modulates the radiosensitivity of lung cancer cells via the MAPK/ERK signaling pathway. PMID: 23589165
- Cdc7 phosphorylates and interacts with Tob to inhibit the Cul4-DDB1(Cdt2)-dependent Tob degradation. PMID: 23066029
- The study demonstrates that the overexpression of TOB1 inhibits gastric cancer progression by activating Smad4- and inhibiting betacatenin-mediated signaling pathways. PMID: 22710759
- TOB1 overexpression not only increased the expression of the phosphatase and tensin homolog (PTEN), an important tumor suppressor, but also regulated the downstream effectors in the PI3K/PTEN signaling pathway, including Akt, ERK1/2, etc. PMID: 22158108
- The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked. PMID: 22252318
- Silencing of HIC1 and TOB1 expression is a common occurrence in gastric cancer and may contribute to the development and progression of the disease. PMID: 21533545
- Longer survival was associated with hypomethylation at specific CpG sites (e.g., GREB1, TGIF, and TOB1) and hypermethylation in other genes (e.g., TMCO5, PTPRN, and GUCY2C). PMID: 21577013
- These results indicate that Tob mediates the recruitment of Caf1 to the target of CPEB3 and elicits deadenylation and decay of the mRNA. PMID: 21336257
- Tob interacts with Caf1 and a C-terminal domain of PABPC1. PMID: 20595394
- TOB1 functions as a lateral signal transmitter. PMID: 11904957
- Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. The C-terminal regions are necessary and sufficient to control the stabilities of BTG1, BTG2, Tob, and Tob2 proteins. PMID: 12135500
- TOB1 has been identified as a MAPK substrate. PMID: 12151396
- Decreased expression or phosphorylation status of the tob protein is associated with lung cancer. PMID: 14643028
- The N-terminal region of TOB1 is a functional nuclear export signal. PMID: 15051490
- Tob is involved in the translational suppression of IL-2 mRNA in anergic T cells through its interaction with iPABP. PMID: 15676026
- TOB1 is a novel target for degradation by the SCF-Skp2 ubiquitin ligase in a cell line. PMID: 16951159
- Reverse-transcription polymerase chain reaction confirmed increased expression of GADD45A, BTG2, PDE4B, and CEBPD and downregulation of TOB1 in skeletal muscle intradialysis. PMID: 16997058
- Subtractive hybridization identified Twisted gastrulation (Tsg) as one of the genes suppressed by Tob. PMID: 17164348
- Data show that TOB1 enhances mRNA deadenylation in vivo, and that interaction with PABPC1 is necessary for TOB1's deadenylation-enhancing effect. PMID: 17785442
- The antiproliferative region of human Tob (residues 1-138) and intact hCaf1 were co-expressed in Escherichia coli, purified, and successfully cocrystallized. PMID: 18084094
- Tob associates with the CCR4-NOT complex. PMID: 18377426
- A positive correlation of TOB1 phosphorylation status with proliferation marker Ki67 suggests that elevated TOB1 phosphorylation might abrogate the antiproliferative effect of TOB1 in breast cancer. PMID: 19491269
- Down-regulation of TOB1 is associated with breast cancer tumorigenesis. PMID: 19569230
Database Links
Protein Families
BTG family
Subcellular Location
Cytoplasm. Nucleus.
Tissue Specificity
Ubiquitous.
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