toca-2 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
toca-2 antibody; K08E3.3 antibody; Transducer of Cdc42-dependent actin assembly protein 2 homolog antibody
Target Names
toca-2
Uniprot No.
Target Background
Function
TOCA-2 plays a crucial role in several cellular processes, including protein trafficking, actin organization, and embryonic morphogenesis. It is believed to act as a cdc-42 effector, potentially influencing egg laying. In collaboration with TOCA-1, it is essential for regulating protein trafficking, specifically controlling clathrin-mediated endocytosis of yolk proteins during oocyte development. This collaboration also facilitates retrograde recycling and sorting of recycling endosome cargo proteins such as MIG-14. Furthermore, TOCA-2, in conjunction with TOCA-1, governs the distribution of actin at cell junctions.
Gene References Into Functions
- TOCA-1 and TOCA-2 are essential for regulating clathrin-mediated endocytic processes during oocyte growth and for controlling epithelial morphogenesis in developing embryos. PMID: 19798448
Database Links
Protein Families
FNBP1 family
Subcellular Location
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Recycling endosome.
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