top-2 Antibody
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Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
top-2 antibody; K12D12.1 antibody; DNA topoisomerase 2 top-2 antibody; EC 5.6.2.2 antibody; DNA topoisomerase II antibody
Target Names
top-2
Uniprot No.
Target Background
Function
This antibody targets Topoisomerase II, an enzyme crucial for controlling the topological states of DNA. Its mechanism involves the transient breakage and subsequent rejoining of DNA strands, creating double-strand breaks. Topoisomerase II is essential for several critical processes: proper chromosome segregation during mitosis in the adult germline and embryogenesis; centromere resolution during mitosis; chromosome segregation in anaphase I of meiosis during spermatogenesis; cleavage furrow stability during cytokinesis in the presence of chromatin obstructions; and DNA break formation during zygotic genome activation in primordial germ cells, thereby activating a checkpoint response. It plays an essential role in embryogenesis.
Gene References Into Functions
- Topoisomerase II promotes chromosome-length shortening. PMID: 28733327
- Studies using *C. elegans* have highlighted the differential effects of various poisons on hTOPIIα and hTOPIIβ, demonstrating the utility of this model organism for understanding the genetics of drug responses. PMID: 28700616
- A novel Top2 mutation disrupts chromosome segregation during spermatogenesis. PMID: 27707787
Database Links
Protein Families
Type II topoisomerase family
Subcellular Location
Nucleus, nucleoplasm. Chromosome. Cytoplasm, cytoskeleton, spindle.
Tissue Specificity
Expressed in the hermaphrodite and male germline.
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