Tpst2 Antibody

1. Studies on mice with a genetic defect in the Tpst2 gene (grt/grt) have revealed cerebral abnormalities characterized by cortical hypoplasia at the frontooccipital axis. These abnormalities are associated with immature pyramidal neurons and insufficient development of callosal fibers. PMID: 25231844
2. Research indicates that the low body weight and salivary gland hypofunction observed in Tpst2-/- mice are primarily due to hypothyroidism. PMID: 23951251
3. The absence of tyrosylprotein sulfotransferase-2 activity leads to alterations in sperm-egg interactions and a reduction in ADAM3 and ADAM6 levels in epididymal sperm. PMID: 21339297
4. Experimental evidence demonstrates that the Tpst2 transgene effectively rescues the mutant phenotypes both in vitro and in vivo. PMID: 20622471
5. Given that Tpst2 is the gene responsible for the grt phenotype, and its mutation is linked to impaired function of the TSH receptor, these findings suggest a potential involvement of factors including Tpst2 in insulin hyposecretion in grt mice. PMID: 20488945
6. Research findings conclusively demonstrate that TPST-1 and TPST-2 play distinct biological roles in vivo. Moreover, these studies highlight the critical importance of protein-tyrosine O-sulfation in male fertility. PMID: 16469738
7. The growth-retarded (grt) mutation results in a loss of TPST2 activity. Notably, the TPST2 isoform exhibits a high degree of substrate preference for the TSH receptor (TSHR). PMID: 17456791
8. Studies have shown that RNase 9 and Mfge8 are tyrosine-sulfated in wild type and Tpst1(-/-), but not in Tpst2(-/-) mice. This suggests that the lack of sulfation of one or both of these proteins may contribute to the infertility observed in Tpst2(-/-) males. PMID: 19047058

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KEGG: mmu:22022

STRING: 10090.ENSMUSP00000031287

UniGene: Mm.250631