TRIM38 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
We are typically able to dispatch orders within 1-3 business days of receipt. Delivery times may vary depending on the method of purchase and location. Please consult your local distributor for specific delivery timeframes.
Synonyms
TRIM38 antibody; RNF15 antibody; RORET antibody; E3 ubiquitin-protein ligase TRIM38 antibody; EC 2.3.2.27 antibody; RING finger protein 15 antibody; RING-type E3 ubiquitin transferase TRIM38 antibody; Tripartite motif-containing protein 38 antibody; Zinc finger protein RoRet antibody
Target Names
TRIM38
Uniprot No.
Target Background
Function
TRIM38 is an E3 ubiquitin-protein ligase that mediates Lys-48-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1. This process inhibits TLR3-mediated type I interferon signaling.
Gene References Into Functions
- Research suggests that mRNA and protein levels of NLRP6 are downregulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients. NLRP6 serves as a docking site to facilitate interaction between TAB2/3 and TRIM38 in RA synoviocytes in response to TNFalpha. (NLRP6 = ; TAB2/3 = transforming growth factor-b-activated kinase 1-binding protein 2/3; TRIM38 = tripartite motif 38) PMID: 28295271
- TRIM38 may function as a novel negative regulator of TLR3-mediated type I interferon signaling by targeting TRIF for degradation. PMID: 23056470
- NF-kappaB is activated in response to TRIM38. PMID: 21789858
- Enterovirus 71 infection leads to degradation of TRIM38. PMID: 21306652
Database Links
Tissue Specificity
Ubiquitous.
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