TRIOBP Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship your orders within 1-3 business days of receiving them. Delivery times may vary depending on the purchase method and location. Please consult your local distributors for specific delivery timelines.
Synonyms
TRIOBP antibody; KIAA1662 antibody; TARA antibody; HRIHFB2122 antibody; TRIO and F-actin-binding protein antibody; Protein Tara antibody; Trio-associated repeat on actin antibody
Target Names
TRIOBP
Uniprot No.
Target Background
Function
TRIOBP is a protein that may regulate actin cytoskeletal organization, cell spreading, and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. TRIOBP may also serve as a linker protein to recruit proteins required for F-actin formation and turnover.
Gene References Into Functions
- Research indicates that Tara forms a functional complex with Ndel1, influencing its intracellular distribution. The Ndel1-Tara complex plays a role in regulating actin cytoskeleton organization, a critical process for cell migration. PMID: 27546710
- Case reports have identified novel TRIOBP mutations associated with moderate, stable hereditary hearing impairment. PMID: 28089734
- Whole exome analysis has revealed two TRIOBP pathogenic variants (c.802_805delCAGG, p.Gln268Leufs*610 and c.5014G>T, p.Gly1672*, the first being novel) as causative for nonsyndromic, peri- to postlingual, moderate-to-severe hearing loss in three siblings from a Polish family. PMID: 29197352
- TRIOBP-1 aggregation appears to occur through specific cellular mechanisms, potentially relevant to the biological processes underlying chronic mental illness development. PMID: 28438837
- Two genome-wide significant SNPs were identified. The first, novel, was near ISG20. The second was in TRIOBP, a gene previously associated with prelingual nonsyndromic hearing loss. Based on the TRIOBP results, further examination of exons in known hearing loss genes identified two additional SNPs, rs2877561 in ILDR1 and rs9493672 in EYA4 (at a significance threshold adjusted for the number of SNPs in those regions). PMID: 27764096
- TRIOBP-1 aggregates are implicated for the first time as a biological element in the neuropathology of a subset of chronic mental illness. PMID: 25333879
- High TRIOBP expression is associated with pancreatic cancer. PMID: 25130170
- TAP68 plays a role in mediating TRF1-tankyrase 1 localization to the centrosome and in mitotic regulation. PMID: 24692559
- The centrosomal localization of Tara depended on Thr-457 phosphorylation and the kinase activity of Plk1. PMID: 22820163
- Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are linked to nonsyndromic recessive deafness. PMID: 16385457
- Mutations in a novel isoform of TRIOBP, encoding a filamentous-actin binding protein, are responsible for DFNB28 recessive nonsyndromic hearing loss. PMID: 16385458
- These findings suggest that HECTD3 may facilitate cell cycle progression by regulating ubiquitination and degradation of Tara. PMID: 18194665
Database Links
Involvement In Disease
Deafness, autosomal recessive, 28 (DFNB28)
Subcellular Location
Nucleus. Cytoplasm, cytoskeleton.; [Isoform 1]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody.
Tissue Specificity
Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.
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