TRIP13 Antibody
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Product Specs
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship your orders within 1-3 business days of receiving them. Delivery times may vary depending on the order method and location. Please contact your local distributor for specific delivery timelines.
Synonyms
16E1-BP antibody; 16E1BP antibody; Homo sapiens HPV16 E1 protein binding protein mRNA complete cds antibody; HPV16 E1 protein binding protein antibody; HPV16 E1 protein-binding protein antibody; Human papillomavirus type 16 E1 protein binding protein antibody; Human papillomavirus type 16 E1 protein-binding protein antibody; Pachytene checkpoint protein 2 homolog antibody; PCH2 antibody; Thyroid hormone receptor interactor 13 antibody; Thyroid receptor interacting protein 13 antibody; Thyroid receptor-interacting protein 13 antibody; TR-interacting protein 13 antibody; TRIP-13 antibody; Trip13 antibody; TRP13_HUMAN antibody
Target Names
TRIP13
Uniprot No.
Target Background
Function
TRIP13 plays a crucial role in chromosome recombination and structure development during meiosis. It is essential for the initial steps of meiotic recombination, leading to non-crossover pathways. Additionally, TRIP13 is required for efficient homologous synapsis by influencing crossover distribution along chromosomes, impacting both crossover and non-crossover pathways. It is also vital for the development of higher-order chromosome structures and is necessary for synaptonemal complex formation. In males, TRIP13 is required for efficient synapsis of sex chromosomes and sex body formation. Furthermore, TRIP13 promotes the initial steps of DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. It is also required for the depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Finally, TRIP13 plays a role in mitotic spindle assembly checkpoint (SAC) activation.
Gene References Into Functions
- Elevated TRIP13 expression appears to promote lung adenocarcinoma tumor progression. PMID: 29567476
- TRIP13-p31(comet) intercepts and disassembles free mitotic checkpoint complex not bound to anaphase-promoting complex/cyclosome through mediating the local unfolding of the Mad2 C-terminal region. PMID: 29208896
- Microarray analyses indicate that TRIP13's biological function in CLL primarily involves cell apoptosis and proliferation. Cells expressing TRIP13 siRNA exhibit a slower cell proliferation rate and undergo apoptosis compared to control cells. PMID: 28424416
- TRIP13 ubiquitinates and degrades the checkpoint surveillance protein MAD2 by activating Akt signaling pathway, leading to weakened checkpoint surveillance and subsequent tumorigenic aneuploidy and drug resistance in MM. PMID: 28157697
- These findings reveal an unexpected dependency on TRIP13 in cells overexpressing Mad2. PMID: 28564602
- Six individuals with biallelic loss-of-function mutations in TRIP13 developed Wilms tumors. TRIP13-mutant patient cells lack detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC), resulting in a high rate of chromosome missegregation. Individuals with biallelic TRIP13 mutations have a heightened risk of embryonal tumors. These experiments demonstrate that their cells exhibit severe SAC impairment. PMID: 28553959
- These authors demonstrate that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 in the presence of ATP. PMID: 28659378
- These results establish a model for the roles of p31(comet) and TRIP13 in both checkpoint activation and inactivation. PMID: 26832417
- The oligomeric form of TRIP13 binds both p31(comet) and MCC. PMID: 26324890
- TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer. PMID: 25078033
- These findings suggest that premature mitotic checkpoint silencing triggered by TRIP13 overexpression may promote cancer development. PMID: 25012665
- This research proposes that TRIP13 plays central roles in the sequence of events leading to MCC disassembly and checkpoint inactivation. PMID: 25092294
Database Links
Involvement In Disease
Mosaic variegated aneuploidy syndrome 3 (MVA3)
Protein Families
AAA ATPase family, PCH2 subfamily
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