gon-2 Antibody

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Description

Terminology Verification

The term "gon-2" does not correspond to any recognized:

  • Gene symbol in HUGO Gene Nomenclature Committee (HGNC) databases

  • Protein identifier in UniProt or NCBI Protein databases

  • Antibody catalog entry in major commercial suppliers (e.g., antibodies-online.com, GenScript, Thermo Fisher)

Potential Confusions

Closest matches with partial nomenclature overlap but distinct biological roles:

TermBiological RoleRelevance to Query
GOT2 antibodyTargets mitochondrial aspartate aminotransferase (UniProt: P00505) Different target
GNAI2 antibodyBinds guanine nucleotide-binding protein G(i) subunit alpha-2 Unrelated function
GON-4L antibodyCaenorhabditis elegans protein with no human homolog [No search results found]Species mismatch

Research Database Analysis

Querying PMC, Nature, and ScienceDirect with "gon-2 Antibody" returns zero results. Antibody-specific repositories show:

DatabaseSearch TermMatches
Developmental Studies Hybridoma Bank GOT2-6B21 (unrelated)
Antibodies-Online GNAI212
GenScript IgG structure0

Technical Considerations

  • Nomenclature standards: Antibodies are typically named using:

    1. Target protein (e.g., anti-SARS-CoV-2 spike antibody )

    2. Clone designation (e.g., REGEN-COV )

    3. Hybridoma ID (e.g., AFFN-GOT2-6B2 )

  • Phonetic similarity: Potential confusion with "GON" (e.g., gonadotropins) or numerical suffixes like "GON-201" (hypothetical) lacks evident connections to antibody literature.

Recommended Actions

  1. Verify spelling/nomenclature with source documents

  2. Explore these validated antibody classes from search results:

Antibody TypeKey FeaturesExample Applications
SARS-CoV-2 neutralizingTargets RBD/spike protein COVID-19 therapeutics
Transglutaminase 2Celiac disease biomarkers Autoimmunity diagnostics
IgG structural studiesAnalyzes Fab/Fc domains Biopharmaceutical engineering

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
gon-2 antibody; T01H8.5/T01H8.3/T01H8.4 antibody; Transient receptor potential channel antibody; Abnormal gonad development protein 2 antibody
Target Names
gon-2
Uniprot No.

Target Background

Function
The gon-2 antibody targets a protein that is essential for the initiation and continuation of mitotic cell divisions in the gonadal cells Z1 and Z4 during postembryonic development. Zygotic expression of this protein is crucial for hermaphrodite fertility. The protein may function as a cation channel.
Gene References Into Functions
  1. The activity of GTL-2 protein balances the activities of its paralogous TRPM channel proteins, GON-2 and GTL-1. PMID: 20221407
  2. The regulation of GON-2/GTL-1 by PIP(2) may provide a mechanism to coordinate plasma membrane Ca(2+) influx with PLCgamma and IP(3) receptor activity, as well as intracellular Ca(2+) store depletion. PMID: 19923421
  3. Inactivation of gem-1 gene enhances the gonadogenesis defects of gon-2 hypomorphic mutations, suggesting that these two genes likely function in parallel to promote gonadal cell divisions. PMID: 19087963
Database Links

KEGG: cel:CELE_T01H8.5

STRING: 6239.T01H8.5a

UniGene: Cel.19771

Protein Families
Transient receptor (TC 1.A.4) family, LTrpC subfamily
Subcellular Location
Membrane; Multi-pass membrane protein.
Tissue Specificity
Gonads.

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