TSGA10 Antibody
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In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your orders. Delivery time may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery time information.
Synonyms
Cancer/testis antigen 79 antibody; CEP4L antibody; CT79 antibody; Predicted testis protein antibody; Testis development protein NYD-SP7 antibody; Testis-specific gene 10 protein antibody; Testis-specific protein 10 antibody; TSG10_HUMAN antibody; Tsga10 antibody
Target Names
TSGA10
Uniprot No.
Target Background
Function
TSGA10 plays a significant role in spermatogenesis. Its overexpression inhibits the nuclear localization of HIF1A.
Gene References Into Functions
- TSGA10 tends to express variants with shorter 5'UTRs. PMID: 28739310
- Overexpression of TSGA10 disrupts the HIF-1alpha axis, leading to potent inhibitory effects on tumor angiogenesis and metastasis. PMID: 26573430
- Research suggests a role for the mir-577/TSGA10 axis in regulating esophageal squamous cell carcinoma progression. PMID: 24294352
- TSGA10 is considered an autoantigen in a subset of autoimmune polyendocrine syndrome type 1 patients and a minority of systemic lupus erythematosus patients. PMID: 21198756
- TSGA10 may influence the function of antigen-presenting cells through its interaction with cytoskeletal proteins such as vimentin. PMID: 20797700
- TSGA10 is overexpressed in a subset of cancers including: 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. PMID: 15107545
- RT-PCR analysis of TSGA10 expression can aid in the detection of residual clonal cells, facilitating early diagnosis and better prognostic assessment of acute lymphoblastic leukemia. PMID: 16406020
- TSGA10 is a target of immune reactions in Autoimmune polyendocrine syndrome type 1 (APS1). PMID: 18000009
Database Links
Protein Families
CEP135/TSGA10 family
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Tissue Specificity
Expressed in the testis, in spermatozoa (at protein level). Expressed in actively dividing fetal tissues, including sternum, intestine, limb, kidney and stomach.
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