TSPAN2 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (12-14 weeks)
Synonyms
TSPAN2; Tetraspanin-2; Tspan-2; Tetraspan NET-3
Target Names
TSPAN2
Uniprot No.
Target Background
Function
TSPAN2 plays a crucial role in signaling within oligodendrocytes during the early stages of their terminal differentiation into myelin-forming glia. It may also contribute to the stabilization of the mature myelin sheath.
Gene References Into Functions
- Research has identified TSPAN2 as a potential candidate gene involved in Blood Pressure Regulation, regulated by heritable DNA methylation. PMID: 29198723
- TSPAN2 appears to promote apoptosis of RNAKT-15 cells by modulating the JNK/beta-catenin pathway in response to high glucose concentrations. Targeting TSPAN2 could potentially offer a therapeutic approach to address glucose toxicity-induced beta-cell failure. PMID: 27247127
- A novel locus (G allele at rs12122341) located near TSPAN2 on chromosome 1p13.2 has been linked to large artery atherosclerosis-related stroke. PMID: 26708676
- Studies suggest that TSPAN2 contributes to the early stages of oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 may play a role in the progression of tumor metastasis by influencing cancer cell motility and invasion functions. PMID: 28408487
- TSPAN2 has been identified as a factor contributing to invasion, motility, and metastasis. PMID: 24726368
- The C-allele of rs2078371 near TSPAN-2 has also been associated with migraine at a genome-wide significance level. PMID: 23294458
Database Links
Protein Families
Tetraspanin (TM4SF) family
Subcellular Location
Membrane; Multi-pass membrane protein.
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