ttn-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
ttn-1 antibody; W06H8.8 antibody; Titin homolog antibody; EC 2.7.11.1 antibody
Target Names
ttn-1
Uniprot No.
Target Background
Function
TTN-1, a serine/threonine-protein kinase, plays a pivotal role in muscle assembly and function. It contributes to the delicate equilibrium of forces within the sarcomere by establishing connections between individual microfilaments. The extensibility of the sarcomere in muscle is significantly influenced by the size and flexibility of these cross-links. In non-muscle cells, TTN-1 is implicated in chromosome condensation and segregation during mitosis. It may potentially link the lamina network to chromatin or nuclear actin, or both, during interphase.
Gene References Into Functions
- The presence of extended, modular, and unstable alpha-helical oligomerization domains within the BLUE region of TTN-1 could facilitate bundling of TTN-1 and stabilize the oblique striation of the sarcomere. PMID: 20346955
Database Links
STRING: 6239.W06H8.8g
UniGene: Cel.20750
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Subcellular Location
Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, myofibril, sarcomere, I band. Nucleus membrane; Peripheral membrane protein.
Tissue Specificity
Expression is restricted to body wall, enteric and vulval muscles.
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