ttr-52 Antibody

TTR-52 antibody plays a crucial role in the clearance of apoptotic cells by acting as a bridging molecule. It facilitates recognition and engulfment by cross-linking phosphatidylserine exposed on the surface of apoptotic cells with the extracellular domain of the phagocyte receptor CED-1. This interaction is essential for the formation of phosphatidylserine vesicles, which promote the loss of the exoplasmic leaflet from apoptotic cells in a time-dependent manner. TTR-52 is required for the exposure of the exoplasmic leaflet on the phagocytic cells surrounding the apoptotic cells. Importantly, it does not affect phosphatidylserine externalization in living cells. TTR-52 may be involved in mediating the transfer of phosphatidylserine from phosphatidylserine vesicles to CED-1 bearing phagocytes, or alternatively, it might activate a phosphatidylserine transporter in the phagocyte, promoting phosphatidylserine externalization.