TUBG1 Antibody

1. CCT actively promotes the formation of conformationally distinct aggregates of gamma-tubulin, a non-amyloidogenic CCT client protein. These aggregates are mediated by specific interactions between CCT and gamma-tubulin. PMID: 29339327
2. Studies indicate that the accumulation of gamma-tubulin-2 in mature neurons and neuroblastoma cells during oxidative stress, despite predominant expression of gamma-tubulin-1, suggests a prosurvival role for gamma-tubulin-2 in neurons. PMID: 28119396
3. All GCPs are incorporated into the helix through lateral interactions between their N-terminal domains, while the C-terminal domains mediate longitudinal interactions with gamma-tubulin. PMID: 27660388
4. While binding to gamma-tubulin may facilitate the targeting of APC to the microtubule nucleation complexes, additional C-terminal sequences of APC are necessary to stimulate and stabilize microtubule growth. PMID: 26556314
5. Research indicates that CUL4A- and CUL4B-mediated polyubiquitination of gamma-tubulin leads to its degradation. PMID: 25542213
6. This study elucidated the molecular basis of interaction between two lateral gamma-tubulin units within the gamma-tubulin ring complex by extensively employing molecular mechanics and molecular dynamics techniques. PMID: 25031076
7. Gamma tubulin expression correlated with patients' age, astrocytoma grade, respectability, patient survival, and performance. These factors may serve as significant prognostic indicators for patients with astrocytomas. PMID: 24620973
8. In vitro studies demonstrate that recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A. PMID: 23966160
9. Nek9 phosphorylates NEDD1 at Ser377, driving its recruitment, and consequently that of gamma-tubulin, to the centrosome in mitotic cells. PMID: 22818914
10. Our findings reveal, for the first time, an increased expression of TUBG1 and TUBG2 in lung cancer. PMID: 22806905
11. Overexpression of Cdk1 or BRCA1 significantly expands the gamma-tubulin coating of microtubules, suggesting a role for microtubule-bound gamma-tubulin in DNA damage response. PMID: 21951856
12. In both transformed and non-transformed interphase mammalian cells, gamma-tubulin is present not only in the cytoplasm but also in the nucleus and nucleoli, where it can be translocated during mitosis. PMID: 21465471
13. These results identify Cep70 as a crucial centrosomal protein that interacts with gamma-tubulin and emphasize its critical role in regulating mitotic spindle assembly. PMID: 21795687
14. The data presented here indicate a significant relationship between gamma-tubulin and actin filament dynamics. PMID: 21473851
15. Direct interaction with NEDD1 regulates the recruitment of gamma-tubulin to the centrosome. PMID: 20224777
16. The 2.7-A crystal structure of human gamma-tubulin bound to GTP-gammaS (a non-hydrolysable GTP analogue) has been determined. PMID: 15917813
17. Analysis has been conducted on human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin. PMID: 17102634
18. Data suggests a link between aberrant expression and interactions of betaIII-tubulin and gamma-tubulin and malignant changes in glial cells. PMID: 17406983
19. GSK-3beta regulates the localization of the gamma-tubulin ring complex, including GCP5, to the spindle poles, thereby controlling the formation of proper mitotic spindles. PMID: 18316369
20. The axial elastic modulus of tubulin decreases as the length of the monomer increases. PMID: 18621829
21. Increased expression of centrosomal TUBG in atypical ductal hyperplasia and carcinoma of the breast has been reported. PMID: 19215229
22. The stability of the small gamma-tubulin complex (gamma tubulin/GCP2/GCP3) requires HCA66, a protein found in the centrosome and the nucleolus. PMID: 19299467
23. Data suggests that sequential phosphorylation of Nedd1 by Cdk1 and Plk1 plays a role in targeting the gamma tubulin ring complex to the centrosome by promoting the interaction of Nedd1 with the gammaTuRC component gamma-tubulin, during mitosis. PMID: 19509060
24. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. PMID: 19543530
25. SADB kinase activity regulates centrosome homeostasis by controlling the phosphorylation of gamma-tubulin. PMID: 19648910

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HGNC: 12417

OMIM: 191135

KEGG: hsa:7283

STRING: 9606.ENSP00000251413

UniGene: Hs.279669