ECH Antibody

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Description

Terminology Analysis

The term "ECH" does not align with standardized antibody nomenclature (e.g., IgG, IgA) or established naming conventions for monoclonal antibodies (e.g., "-mab" suffix for therapeutic antibodies). Potential interpretations include:

  • Typographical error: Possible intended terms include "EpCAM Antibody" (e.g., Edrecolomab ) or "ECH1" (a mitochondrial enzyme unrelated to antibodies).

  • Proprietary or developmental name: Unpublished or pre-clinical antibodies may use internal codes not yet documented in public repositories.

Antibody Classification and Structure

Antibodies are categorized by isotype, target specificity, and structural features (Table 1). None of these categories correlate with "ECH" in the reviewed sources.

FeatureDescriptionExamples
IsotypeDetermined by heavy-chain constant regions (IgG, IgA, IgM, IgE, IgD)IgG1 (Eculizumab ), IgM pentamers
TargetAntigen specificity (e.g., viral proteins, cell receptors)PCSK9 (Evolocumab ), HER2 (Margetuximab )
FormatMonospecific, bispecific, or engineered fragments (e.g., Fab, scFv)Epcoritamab (bispecific ), scFv libraries
EngineeringModifications for enhanced function (e.g., Fc silencing, glycoengineering)Eptinezumab (aglycosylated )

Research and Therapeutic Antibody Databases

Key databases were analyzed for "ECH" references (Table 2):

DatabaseContentFindings
AbDb PDB-derived antibody structuresNo entries matching "ECH"
EV Antibody DB Validated antibodies for extracellular vesiclesNo "ECH" records
AACDB Antigen-antibody complexes7,498 entries; none labeled "ECH"
Antibody Therapeutics FDA/EMA-approved therapies120+ entries; no "ECH"-related candidates

Hypothetical Scenarios

If "ECH Antibody" exists, it might represent:

  1. Novel target: An antibody against an uncharacterized epitope (e.g., internal viral proteins ).

  2. Experimental candidate: Preclinical antibodies not yet published (e.g., SARS-CoV-2 binders ).

  3. Acronym misinterpretation: Potential mislabeling of "E" (e.g., IgE) or "CH" (constant heavy chain ).

Recommendations for Further Research

  1. Verify the spelling and context of "ECH" with the original source.

  2. Explore proprietary pharmaceutical pipelines or niche immunological studies.

  3. Investigate non-English literature for regional naming variants.

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
ECH; At1g09330; T31J12.5; Golgi apparatus membrane protein-like protein ECHIDNA
Target Names
ECH
Uniprot No.

Target Background

Function
ECH Antibody mediates trans-Golgi-network trafficking and cell elongation. It is essential for maintaining the balance between secretory trafficking and vacuolar targeting of specific proteins. The ECH/YIP4 complex plays a crucial role in regulating the trans-Golgi network (TGN)-mediated trafficking of certain proteins and cell wall components (e.g., pectin and hemicellulose) to the cell wall in dark-grown hypocotyls and secretory cells of the seed coat.
Gene References Into Functions
  1. ECH expression is critical for various aspects of male reproduction, including the production of functional pollen grains, their effective release, germination, and tube formation. PMID: 24424320
  2. ECH protein is essential for the trans-Golgi network-mediated trafficking of the auxin influx carrier AUX1 to the plasma membrane. [ECH] PMID: 24043780
Database Links

KEGG: ath:AT1G09330

STRING: 3702.AT1G09330.1

UniGene: At.43661

Protein Families
TVP23 family
Subcellular Location
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

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