hlh-8 Antibody
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Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
hlh-8 antibody; C02B8.4 antibody; Twist-related protein antibody; CeTwist antibody; Helix-loop-helix protein 8 antibody
Target Names
hlh-8
Uniprot No.
Target Background
Function
HLH-8, a basic helix-loop-helix (bHLH) transcription factor, plays a crucial role in regulating gene expression. It is involved in the determination of cell fate during mesoderm development, particularly in the postembryonic stages. HLH-8 activates the expression of genes like *ceh-24* and *egl-15*, contributing to the precise patterning of mesodermal tissues.
Gene References Into Functions
- Studies have shown that HLH-8 homodimers are essential for the proper development of M lineage patterning and enteric muscles, while HLH-8/HLH-2 heterodimers play a significant role in the formation of M-derived vulval muscles. PMID: 22275075
- The expression of *hlh-8* in differentiated mesodermal cells is tightly regulated by two conserved E box elements located within the large first intron of the gene. PMID: 20691175
Database Links
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in defecation-associated muscles and neuron-like cells in the head at the L1 stage. In later larvae, expressed in SM cells and their descendants. Not expressed in differentiated body wall or sex muscles.
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