uaf-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
uaf-1 antibody; Y92C3B.2 antibody; Splicing factor U2AF 65 kDa subunit antibody; U2 auxiliary factor 65 kDa subunit antibody; U2AF65 antibody; U2 snRNP auxiliary factor large subunit antibody
Target Names
uaf-1
Uniprot No.
Target Background
Function
UAF-1 plays a crucial role in pre-mRNA splicing. It binds to the polypyrimidine tract within introns during the early stages of spliceosome assembly, facilitating the splicing process.
Gene References Into Functions
- WDR-20 and WDR-48, in conjunction with USP-46, form a complex that deubiquitinates and stabilizes GLR-1 in vivo. PMID: 24356955
- The interaction of TEG-1 CD2BP2 with UAF-1 U2AF65, alongside its previously established function in U4/U6.U5 tri-snRNP, suggests that TEG-1 CD2BP2 participates in distinct locations within the splicing cascade. PMID: 22275078
- Mutations within the U2AF large subunit, a splicing factor, have been observed to alter the splicing of tos-1. 3' splice sites. PMID: 22033331
- Research findings provide in vivo evidence that UAF-1 can regulate 3' splice-site selection. This establishes a system for investigating the in vivo regulation of RNA splicing in C. elegans. PMID: 19893607
Database Links
Subcellular Location
Nucleus.
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