ubald2 Antibody

UBALD2 Antibody Characteristics

UBALD2 antibodies are immunoglobulin proteins designed to specifically bind to epitopes within the UBALD2 protein. Key features include:

Research Applications

UBALD2 antibodies are validated for use in multiple experimental workflows:

• Immunohistochemistry (IHC): Detects UBALD2 expression in formalin-fixed, paraffin-embedded tissues .

• Western Blot (WB): Identifies UBALD2 in lysates with minimal cross-reactivity .

• Blocking Peptide Studies: Synthetic peptides (e.g., Catalog No. ABIN976580) are used to validate antibody specificity by competitively inhibiting binding .

Key Validation Data:

• A polyclonal antibody (Thermo Scientific PA554676) demonstrated reactivity in human samples at a dilution of 1:200 for IHC and 1:1000 for WB .

• Antibodies exhibit 86% sequence identity with mouse UBALD2 and 88% with rat orthologs, supporting cross-species studies .

Functional and Clinical Insights

Despite limited functional data, UBALD2’s UBA-like domain implies involvement in ubiquitin-mediated processes, such as protein degradation or signal transduction . Current research highlights:

• Protein Interactions: UBALD2 may interact with CCDC85B and KPNA3, though mechanistic studies are lacking .

• Disease Relevance: No direct associations with pathologies are reported, but its structural homology to UBA-domain proteins suggests potential roles in cancer or immune regulation .

Limitations and Future Directions

• Uncharacterized Function: UBALD2’s biological role remains undefined, necessitating further studies using targeted antibodies .

• Antibody Specificity: Commercial antibodies require rigorous validation due to potential cross-reactivity with UBA-domain proteins .