ubr-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
ubr-1 antibody; C32E8.11 antibody; E3 ubiquitin-protein ligase ubr-1 antibody; EC 2.3.2.27 antibody; N-recognin-1 antibody; RING-type E3 ubiquitin transferase ubr-1 antibody; Ubiquitin-protein ligase E3-alpha antibody
Target Names
ubr-1
Uniprot No.
Target Background
Function
UBR-1 is an E3 ubiquitin-protein ligase that plays a crucial role in the N-end rule pathway. This pathway targets proteins with specific N-terminal residues for degradation. UBR-1 recognizes and binds to these proteins, triggering their ubiquitination and subsequent degradation. In conjunction with CED-3, UBR-1 is essential for the cleavage and degradation of the heterochronic protein LIN-28, which is involved in regulating seam cell fate patterning during larval development. Furthermore, UBR-1 negatively regulates glutamate metabolism by interacting with the aspartate aminotransferase GOT-1.2. This modulation of glutamate levels likely influences locomotory behavior, particularly backward locomotion or 'reversals'.
Gene References Into Functions
- Research suggests that UBR proteins may regulate glutamate metabolism, a process crucial for neuronal development and signaling. PMID: 29649217
- Studies have shown that the CED-3 caspase and the E3 ubiquitin ligase UBR-1 form a complex that facilitates the recognition and rapid degradation of LIN-28. PMID: 28602583
Database Links
Protein Families
UBR1 family
Subcellular Location
Membrane; Single-pass membrane protein.
Tissue Specificity
Expressed in pharyngeal muscles, body wall muscles and a subset of neurons throughout postembryonic development. Prominently expressed in premotor interneurons, but not expressed in ventral cord motor neurons. Weakly expressed in hypodermal seam cells.
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