UGGT2 Antibody
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In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship products within 1-3 business days after receiving your order. Delivery times may vary depending on the method of purchase and location. Please contact your local distributor for specific delivery information.
Synonyms
UGGT2 antibody; UGCGL2 antibody; UGT2UDP-glucose:glycoprotein glucosyltransferase 2 antibody; UGT2 antibody; hUGT2 antibody; EC 2.4.1.- antibody; UDP--Glc:glycoprotein glucosyltransferase 2 antibody; UDP-glucose ceramide glucosyltransferase-like 1 antibody
Target Names
Uniprot No.
Target Background
Function
The UGGT2 Antibody recognizes glycoproteins with minor folding defects. It reglucosylates single N-glycans near the misfolded region of the protein, acting as a quality control mechanism for protein folding within the endoplasmic reticulum. Reglucosylated proteins are then recognized by calreticulin, facilitating their recycling back to the endoplasmic reticulum for either refolding or degradation.
Gene References Into Functions
- This study sought to elucidate the contribution of noncatalytic domains by comparing the activities of truncated forms of recombinant HUGT1/HUGT2 and HUGT1/HUGT2 chimeras with full-length enzymes. PMID: 27496766
- The glucosyltransferase activity of UGGT2 has remained elusive, leaving its precise role in the glycoprotein folding process unclear. PMID: 24415556
- HUGT2 is incapable of activating the catalytic domain of UDP-glucose: glycoprotein glucosyltransferase I. PMID: 12913004
Database Links
Protein Families
Glycosyltransferase 8 family
Subcellular Location
Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment.
Tissue Specificity
Higher levels in kidney, pancreas, heart, and skeletal muscle.
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