Unc13b Antibody
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Product Specs
Target Background
Function
Unc13b antibody plays a crucial role in vesicle maturation during exocytosis, acting as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release, participating in synaptic vesicle priming before vesicle fusion and contributing to the activity-dependent replenishment of the readily releasable vesicle pool (RRP). Unc13b is essential for synaptic vesicle maturation in a specific subset of excitatory/glutamatergic synapses, but not in inhibitory/GABA-mediated synapses. Collaborating with UNC13A, Unc13b facilitates neuronal dense core vesicle fusion and regulates the location and efficiency of their synaptic release.
Database Links
Protein Families
Unc-13 family
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.
Tissue Specificity
Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain, predominantly in cerebral cortex, hippocampus and striatum.
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