XAF1 Antibody

1. This study reveals the crucial role of XAF1-MT2A antagonism in regulating cell fate under various stressful conditions, including heavy metal exposure. PMID: 28507149
2. XAF1 expression was significantly altered in non-small cell lung cancer tumor samples compared to normal lung tissues. PMID: 28560416
3. XAF1 expression was associated with vascular mimicry (VM) in ovarian cancer, suggesting its potential role in VM formation in epithelial ovarian cancer (EOC). PMID: 28534973
4. XAF1 may be a candidate tumor suppressor in neuroblastoma. PMID: 27097110
5. Dysfunction of XAF1 is frequently observed and regulated through XAF1 promoter hypermethylation in gastric cancer. Circulating methylated XAF1 DNA was associated with tumor burden and malignant progression, indicating its potential as a valuable biomarker for diagnosing gastric cancer, predicting patient prognosis, and monitoring tumor recurrence after surgery treatment. PMID: 23826230
6. XAF1 promoter hypomethylation is associated with high-grade gliomas. PMID: 28122345
7. A human genome-wide gene expression profile assay was used to screen the targets of miR-3131. The overexpression of miR-3131 resulted in a significant decrease in DTHD1 and XAF1 mRNA levels. PMID: 28034876
8. XAF1 acts as a feedback regulator of the TNF receptor signaling pathway to suppress NF-kappaB activation. PMID: 27768232
9. These findings suggest that ROS generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 and GADD45alpha expression by MAPK and functional p53. PMID: 27121748
10. Expression of XAF1 and TAp73 was also upregulated in casticin-treated T24 cells. PMID: 27349281
11. Data indicate that X-linked inhibitor of apoptosis protein (XIAP) mRNA and protein expression increased, while XIAP-associated factor 1 (XAF1) mRNA and protein expression decreased with the growth of radiation dose and exposure time. PMID: 27048285
12. This study was the first to construct an adenovirus co-expressing XAF1 and TNFalpha in the same open reading frame, expressing them proportionally. As AdXAF1&TNFalpha inhibited HCC cells with enhanced efficiency, it could be applicable for the treatment of HCC. PMID: 27121136
13. SHC1 regulates the alternative splicing of XAF1 in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death. PMID: 26643258
14. This research identified a novel splice variant of XAF1 in cancer cells. PMID: 25216542
15. Underexpression of XAF1 confers cisplatin-resistance in ovarian carcinoma. PMID: 25824780
16. Restored XAF1 expression inhibits cell proliferation and induces cell apoptosis in the human lung adenocarcinoma cell line A549. Furthermore, XAF1 may activate associated apoptotic signaling pathways in the A549 cell line. PMID: 25539606
17. Up-regulation of XAF1 distinctly increased apoptosis in colorectal cancer cells administered cisplatin. PMID: 25367849
18. XAF1 stimulates HIPK2-mediated Ser-46 phosphorylation of p53, and XAF1 also enhances the termination of p53-mediated cell-cycle arrest by activating ZNF313. PMID: 25313037
19. XAF1 is a possible sarcoidosis risk gene. PMID: 24663488
20. Transcriptionally active p73 induces translocation of XAF-1 during apoptosis caused by melphalan. XAF-1 directly interacts with Puma and promotes Bax translocation during melphalan-induced apoptosis. PMID: 24249729
21. Promoter methylation of the XAF1 gene plays a significant role in the carcinogenesis and progression of papillary thyroid carcinoma. PMID: 22944270
22. Missense polymorphisms in XIAP-associated factor-1 are associated with papillary thyroid cancer. PMID: 23645777
23. This study investigates the role of XAF1 in promoting apoptosis in vascular endothelial cells after DENV2 infection. PMID: 23207547
24. The search for the XIAP binding region within XAF1 revealed a modest affinity XIAP(RING) binding site located at the C-terminal portion of XAF1. The interaction sites for XAF1(RBD) on XIAP(RING) were also mapped using NMR. PMID: 22811387
25. XAF1 may be involved in ovarian cancer development, and up-regulation of XAF1 may confer sensitivity of ovarian cancer cells to cisplatin-mediated apoptosis. PMID: 22759793
26. XAF1 is frequently methylated in esophageal cancer, and XAF1 expression is regulated by promoter region hypermethylation. PMID: 22719195
27. These findings suggest a potential novel feedback loop exists between XAF1 and wild-type p53. PMID: 21678496
28. The levels of XAF1 protein and mRNA in cancer tissues were significantly lower than those in cancer adjacent and normal lung tissues. PMID: 22088514
29. 5-AZA treatment can induce the expression of XAF1 mRNA and protein in myeloma. PMID: 19549372
30. 5-azacytidine treatment led to XAF1 promoter CpG islands hypomethylation and showed anti-myeloma activity in a time- and concentration-dependent manner. PMID: 19731821
31. XAF1 down-regulation may contribute to prostate cancer development. PMID: 21143993
32. This study demonstrates that p53 could suppress the transcription of XAF1 through interaction with a high affinity responsive element (-95 to -86 nt) within the XAF1 promoter in gastrointestinal cancer cells. PMID: 20198350
33. INFalpha and 5-AZA-CdR can induce Xaf1 mRNA expressions in HL-60 and K562 cells. PMID: 18250043
34. The high expression of HSF1 in gastro-intestinal cancer is associated with suppressed expression of XAF1. PMID: 17884799
35. XAF1 is a valuable prognostic marker in pancreatic cancer and could be a potential candidate for cancer gene therapy. PMID: 19922503
36. The expression levels of the pro-apoptotic XAF-1 gene modulate the cytotoxic response to Nutlin-3 in B chronic lymphocytic leukemia. PMID: 19847196
37. XAF1 augments TRAIL-induced apoptosis. PMID: 12029096
38. Epigenetic silencing of XAF1 by aberrant promoter methylation may contribute to the malignant progression of human gastric tumors. PMID: 14612497
39. XAF1 expression in melanoma tissues was significantly reduced compared with benign melanocytic nevi. PMID: 15610524
40. Endogenous stress pressure in cancer cells sustained the high level expression of HSF1 and subsequently suppressed XAF1 expression, implicating the synergistic effect of two anti-apoptotic protein families in cytoprotection under stressful circumstances. PMID: 16303760
41. The ratio of XAF1(A) and XAF1C mRNA expression differs amongst the cell lines tested, suggesting differential mRNA stabilities and/or the existence of tissue- or cell type-specific splicing regulation. PMID: 16343440
42. Alternative splicing of XAF1 mRNA leads to the formation of a truncated XAF1 protein, which likely affects its functional interaction with XIAP, consequently contributing to the pathogenesis of prostate cancers by disrupting the balance of the apoptosis machinery. PMID: 16353137
43. Gene expression increased in multiple sclerosis patients treated with interferon-beta. PMID: 16459719
44. siRNA to XAF1 inhibited IFN-induced apoptosis; conversely, overexpression of XAF1 overcame resistance to apoptosis induction by IFN-beta. PMID: 16801630
45. Epigenetic alteration of XAF1 is frequent in human urogenital cancers and may contribute to the malignant progression of tumors by rendering tumor cells a survival advantage partially through the attenuated p53 response. PMID: 16909101
46. Down-regulation of XAF1 in association with hypermethylation was detected in 3 of 4 human gastric cancer cell lines and 6 of 8 colon cancer cell lines. PMID: 17087954
47. In the cancerization of oral mucosa, XIAP protein could play an important antiapoptotic role by overexpression, while XAF1 protein does not appear to effectively antagonize the role of XIAP. PMID: 17331366
48. This study provides evidence that XAF1 is a crucial interferon-stimulated gene (ISG) mediator of IFN-induced sensitization to TRAIL in cancer. PMID: 17376236
49. Low XAF1 mRNA expression levels correlate with an unfavorable clinical course in renal cell carcinoma. PMID: 17449173
50. An increased expression ratio of XIAP to XAF1, in combination with a disturbed expression of the XAF1 splice variants, could be shown in gastric adenocarcinomas. PMID: 17471152

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HGNC: 30932

OMIM: 606717

KEGG: hsa:54739

STRING: 9606.ENSP00000354822

UniGene: Hs.441975