BSK1 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
BSK1 antibody; At4g35230 antibody; F23E12.210Serine/threonine-protein kinase BSK1 antibody; EC 2.7.11.1 antibody; Brassinosteroid-signaling kinase 1 antibody
Target Names
BSK1
Uniprot No.
Target Background
Function
BSK1 is a serine/threonine kinase that plays a crucial role in plant development and immunity. It acts as a positive regulator of brassinosteroid (BR) signaling, functioning downstream of the receptor kinase BRI1. BSK1 mediates signal transduction from BRI1 by serving as a substrate for BRI1. Its role extends beyond BR signaling, as it also functions as a positive regulator of plant immunity. BSK1 may be involved in the regulation of pattern-triggered immunity (PTI) downstream of the flagellin receptor FLS2. It exhibits kinase activity in vitro, which is essential for its function in innate immunity.
Gene References Into Functions
- The ability of the kinase domain of BRI1 to generate cGMP is contingent upon its kinase catalytic ability. Notably, cGMP stimulates the phosphorylation of BSK1. Therefore, cGMP is hypothesized to act as a modulator, promoting the activation of downstream phosphorylation events within the BRI1 signaling pathway. PMID: 28482142
- Disruption of BSK1 membrane localization impacts BSK1-FLS2 interactions, suggesting that the membrane association of BSK1 is critical for both edr2-mediated signaling. PMID: 23733062
- BSK1 serves as a positive regulator of defense responses and plays a significant role in pathogen-associated molecular pattern-triggered immunity. PMID: 23532072
- BSK1 is involved in brassinosteroid signal transduction. PMID: 20616146
- Three homologous brassinosteroid (BR)-signaling kinases (BSK1 encoded by At4g35230, BSK2, BSK3) have been identified. These BSKs are phosphorylated by BRI1, and research has demonstrated that they are the substrates of BRI1 kinase, activating downstream BR signal transduction. PMID: 18653891
Database Links
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Subcellular Location
Cell membrane; Lipid-anchor.
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