YAL031W-A Antibody

Definition and Target Specificity

YAL031W-A Antibody targets the protein encoded by the YAL031W-A gene in Saccharomyces cerevisiae. This gene is annotated as a dubious open reading frame (ORF) in the yeast genome, with limited functional characterization . The antibody is produced against a synthetic peptide or recombinant protein corresponding to the YAL031W-A sequence, ensuring specificity for this target.

Biological Context

• Target Protein: YAL031W-A is a putative protein with unknown molecular function. Its gene resides on chromosome I in S. cerevisiae and is classified as "dubious" due to lack of experimental validation .

• Structural Features: Antibodies like YAL031W-A typically bind to epitopes in the variable (Fab) or constant (Fc) regions of immunoglobulins, enabling target detection via methods such as Western blotting .

Research Applications

While direct studies on YAL031W-A are sparse, yeast-derived antibodies are critical for:

• Functional Genomics: Identifying protein interactions in synthetic lethal screens .

• Post-Translational Modification Studies: Investigating phosphorylation or glycosylation patterns in yeast models .

• Comparative Analysis: Serving as controls in experiments involving validated yeast ORFs .

Data Limitations and Gaps

• No peer-reviewed studies specifically addressing YAL031W-A’s role were identified in the provided sources.

• Commercial listings ( ) lack experimental validation data (e.g., binding affinity, cross-reactivity).

Broader Antibody Research Trends

Therapeutic and diagnostic antibody development relies on resources like:

• PLAbDab: A database with ~150,000 antibody sequences, including yeast-derived candidates .

• YAbS: Tracks over 2,900 clinical-stage antibody therapeutics, though none currently target yeast proteins .

Future Directions

• Functional Characterization: Knockout studies to elucidate YAL031W-A’s role in yeast physiology.

• Cross-Reactivity Profiling: Testing against homologous proteins in related fungal species.