SPCC1450.12 Antibody

Key Findings from5:

• Phospholipase Activity: SPCC1450.09c is linked to phospholipase function, critical for membrane remodeling and septum assembly during cell division.

• Cell Wall Dynamics: Deletion or suppression of SPCC1450.09c disrupts β-1,6-glucan synthesis, a polysaccharide essential for septum formation and cell wall stability .

• Genetic Interactions: It interacts with β-1,6-glucanases (e.g., gas2+), which regulate glucan partitioning during septum closure .

From Search Results246:

• Anti-EBV LMP1 (S12): A mouse IgG2a monoclonal antibody targeting EBV-associated cancers, validated for western blot and immunofluorescence .

• Anti-PD-L1 (SP142): A rabbit monoclonal antibody used in cancer immunohistochemistry to detect immune evasion markers .

• VRC01-Class HIV Antibodies: Structurally conserved antibodies derived from IGHV1-2 germline genes, neutralizing HIV via CD4 receptor mimicry .

PBC-Related Autoantibodies38:

• Anti-Sp100: Predictive value for primary biliary cholangitis (PBC), with 98% specificity and 40% prevalence in patients .

• Anti-PML: Achieves 100% positive predictive value for PBC diagnosis .

References

1. Microbenotes: Antibody Structure and Function

2. Kerafast: Anti-EBV LMP1 (S12) Antibody

3. PMC: Autoantibodies in Primary Biliary Cholangitis

4. Abcam: Anti-PD-L1 (SP142) Antibody

5. Heidelberg University: Schizosaccharomyces pombe Sup11p Study

6. Nature: VRC01-Class HIV Antibodies

7. ProSci: Antibody Structure and Properties

8. PMC: PML Autoantibodies in PBC