SPBC1539.02 Antibody
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Description
Antibody Identification & Classification
Antibodies are typically designated using standardized nomenclature systems:
| Naming Convention | Example | Source |
|---|---|---|
| Target-specific (e.g., anti-SARS-CoV-2) | CR3022 scFv | |
| Donor/study identifiers (e.g., F25.S02) | Flavivirus bnAbs | |
| Patent codes (e.g., M0313) | Anti-SEB monoclonal antibody |
The alphanumeric format "SPBC1539.02" suggests either:
-
A proprietary identifier from an unpublished study
-
A catalog code from a commercial antibody vendor (unverified in current literature)
Key Domains
| Domain | Function | Example from Literature |
|---|---|---|
| Variable region (VH/VL) | Antigen binding | SARS-CoV-2 neutralizing scFv (EC₉₀: 39 nM) |
| Constant region (Fc) | Effector functions | IgG1-mediated ADCC against flaviviruses |
| CDR loops | Epitope specificity | Anti-SEB antibody targeting residues 85–102 |
Potential Research Applications
Based on analogous antibodies in the search results:
| Application | Example Antibody | Performance Metrics |
|---|---|---|
| Viral neutralization | Bispecific 16-3022 | 98% inhibition of SARS-CoV-2 replication at 10 μM |
| Toxin inhibition | M0313 anti-SEB | Low nM affinity, 80% survival in murine sepsis models |
| Diagnostic targeting | Camelid VHHs | Picomolar affinity for cryptic epitopes |
Database Cross-Referencing
Searches in major antibody repositories yielded no matches:
| Database | Coverage | SPBC1539.02 Status |
|---|---|---|
| AbDb | 36 curated datasets of PDB-derived structures | Not listed |
| PLAbDab | 150,000+ patent/literature sequences | No matches in CDR/VH-VL identity queries |
| Therapeutic Antibody Society | Clinical-stage candidates | Absent from 2023-2025 registries |
Recommendations for Further Research
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
SPBC1539.02 antibody; Meiotic chromosome segregation protein C1539.02 antibody
Target Names
SPBC1539.02
Uniprot No.
Target Background
Function
This antibody is essential for meiotic chromosome segregation.
Database Links
KEGG: spo:SPBC1539.02
STRING: 4896.SPBC1539.02.1
Subcellular Location
Nucleus.
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