YWHAH Antibody, Biotin conjugated
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship the products within 1-3 business days of receiving your order. Delivery times may vary depending on the method of purchase and location. For specific delivery timeframes, please consult your local distributors.
Synonyms
14 3 3 protein eta antibody; 14-3-3 eta antibody; 14-3-3 protein eta antibody; 1433F_HUMAN antibody; Brain protein 14-3-3; eta isoform antibody; HGNC:12853 antibody; Protein AS1 antibody; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein 1 antibody; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein eta polypeptide antibody; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein; eta isoform antibody; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; eta antibody; Tyrosine 3/tryptophan 5 monooxygenase activation protein eta polypeptide antibody; YWHA 1 antibody; YWHA1 antibody; Ywhah antibody
Target Names
Uniprot No.
Target Background
Function
YWHAZ is an adapter protein involved in regulating a wide array of signaling pathways, both general and specialized. It interacts with numerous partners, typically through recognition of a phosphoserine or phosphothreonine motif. Binding generally results in modulation of the binding partner's activity. YWHAZ negatively regulates the kinase activity of PDPK1.
Gene References Into Functions
- Amplification of YWHAZ has been shown to correlate with improved survival in bladder cancer. Conversely, its knockdown promotes tumorigenesis both in vitro and in vivo, suggesting its potential as a novel biomarker for this disease. PMID: 29512774
- The influence of AKT1 on glucocorticoid receptor (GR)-induced transcriptional activity in conjunction with phospho-serine/threonine-binding protein 14-3-3 was investigated. PMID: 27717743
- The 14-3-3 eta isoform colocalizes with TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis. PMID: 27256400
- Extracellular 14-3-3eta activates key signaling cascades and induces factors linked to the pathogenesis of rheumatoid arthritis. PMID: 24751211
- This study identified YWHAH as a significantly associated locus with a biologically plausible role in schizophrenia. PMID: 24507884
- 14-3-3eta may be essential for mitotic progression and could be considered a novel anti-cancer strategy in combination with microtubule inhibitors. PMID: 22562251
- This is the first genetic association study of YWHAH with sporadic Creutzfeldt-Jakob disease populations. PMID: 21739144
- Relocation of p33ING1b from the nucleus to the cytoplasm, where it is tethered by 14-3-3eta, is implicated in tumorigenesis and progression in HNSCC. PMID: 21432775
- The 14-3-3 eta, beta, gamma and sigma isoforms were found to be negatively expressed in meningioma. PMID: 20388496
- Phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1 by MADM has been reported. PMID: 12176995
- Data demonstrate that 14-3-3 proteins colocalize with Lewy bodies in Parkinson disease, but no specific staining for the 14-3-3 eta subunit was observed. PMID: 12480176
- Gremlin 1, which is overexpressed in human cancers, interacts with the YWHAH protein. PMID: 16545136
- The association of YWHAH with bipolar disorder was investigated in a large sample of 1211 subjects from 318 nuclear families, including 554 affected offspring. PMID: 19160447
Database Links
Protein Families
14-3-3 family
Tissue Specificity
Expressed mainly in the brain and present in other tissues albeit at lower levels.
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