zbtb16a Antibody
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Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
zbtb16a antibody; plzfa antibody; zbtb16 antibody; zgc:55675 antibody; Zinc finger and BTB domain-containing protein 16-A antibody; Promyelocytic leukemia zinc finger protein-A antibody; Zinc finger protein PLZF-A antibody
Target Names
zbtb16a
Uniprot No.
Target Background
Function
This antibody targets ZBTB16A, a protein that likely functions as a transcription factor. It is a potential substrate-recognition component of an E3 ubiquitin-protein ligase complex. This complex plays a crucial role in mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Notably, ZBTB16A has been shown to inhibit neurogenesis.
Gene References Into Functions
- Research findings strongly suggest that a loss of function in the ZBTB16A gene is linked to a partially penetrant, severe cardiac development defect. PMID: 29974860
- While ZBTB16A and ZBTB16B are not modulated by interferon (IFN) produced during viral infection, their overexpression leads to an increased level of the early type I IFN response. This occurs at a critical stage in the host's defense against viral infection. PMID: 26719025
Database Links
Protein Families
Krueppel C2H2-type zinc-finger protein family
Subcellular Location
Nucleus. Cytoplasm.
Tissue Specificity
During early stages of primary neurogenesis, expressed in the neural epithelium, with highest levels in the forebrain and midbrain. Also expressed in a posterior-to-anterior gradient in the caudal neural plate at the 3-6 somite stage.
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