ZFPM2 Antibody
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Description
Introduction to ZFPM2 Antibody
ZFPM2 (Zinc Finger Protein, FOG Family Member 2) antibodies are specialized tools designed to detect and analyze the ZFPM2 protein, a transcription factor critical for developmental processes such as cardiogenesis, lung morphogenesis, and gonadal differentiation . These antibodies are widely used in research to study ZFPM2's role in diseases, including cancer and congenital disorders .
2.1. Target Protein Overview
ZFPM2 (FOG2) interacts with GATA family transcription factors to regulate gene expression . Dysregulation is linked to congenital heart defects, diaphragmatic hernias, and disorders of sex development .
Table 1: ZFPM2 Protein Characteristics
3.1. Cancer Studies
ZFPM2 antibodies have been pivotal in elucidating oncogenic roles of ZFPM2-AS1 (a ZFPM2-associated lncRNA) in cancers:
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Thyroid Cancer: ZFPM2-AS1 knockdown reduced proliferation, migration, and epithelial-mesenchymal transition (EMT) in SW579 and 8505C cells .
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Lung Adenocarcinoma: ZFPM2-AS1 promoted tumor progression via UPF1-mediated ZFPM2 mRNA decay .
Table 3: Key Cancer Research Findings
3.2. Developmental Disorders
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46,XY DSD: Variants in ZFPM2 were identified in patients with hypospadias or ambiguous genitalia, though most were benign .
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Cardiac Defects: ZFPM2 antibodies validated its role in heart morphogenesis via GATA4 interaction .
Validation and Quality Control
Commercial ZFPM2 antibodies undergo rigorous validation:
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Western Blot: Detects ~39–165 kDa bands (varies by isoform) .
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IHC/IF: Confirmed reactivity in human breast cancer and cardiac tissues .
Table 4: Validation Data for Select Antibodies
Product Specs
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Form
Liquid
Lead Time
Generally, we can ship the products within 1-3 business days after receiving your orders. Delivery times may vary depending on the purchase method or location. Please consult your local distributors for specific delivery time estimates.
Synonyms
FOG-2 antibody; FOG2_HUMAN antibody; Friend of GATA 2 antibody; Friend of GATA protein 2 antibody; Friend of GATA2 antibody; hFOG-2 antibody; ZFPM2 antibody; Zinc finger protein 89B antibody; Zinc finger protein M2 antibody; Zinc finger protein multitype 2 antibody; Zinc finger protein ZFPM2 antibody
Target Names
ZFPM2
Uniprot No.
Target Background
Function
ZFPM2 (Zinc Finger Protein, Multitype 2) is a transcription regulator that plays a crucial role in heart morphogenesis and the development of coronary vessels from the epicardium. It achieves this by regulating genes essential during cardiogenesis. ZFPM2 acts as an essential cofactor, forming heterodimers with transcription factors belonging to the GATA family, namely GATA4, GATA5, and GATA6. These heterodimers can either activate or repress transcriptional activity, depending on the cellular and promoter context. ZFPM2 is also involved in gonadal differentiation, potentially by regulating the expression of SRY. It is believed to act as a corepressor of NR2F2.
Gene References Into Functions
- Single nucleotide polymorphisms (SNPs) in NKX2.5, GATA4, and TBX5 are strongly associated with congenital heart diseases in the Chinese population, but SNPs in FOG2 are not significant. PMID: 29972125
- When ZFPM2R698Q was co-transfected with GATA4, BNP promoter activity increased significantly. However, co-transfection with ZFPM2R736L and GATA4 did not lead to a significant increase in BNP promoter activity. This suggests that the R698Q mutation may affect the ability of ZFPM2 to bind GATA4. PMID: 29018978
- Abnormal methylation status at the promoter CpG island shore of the ZFPM2 gene may be associated with its gene transcription regulation in tetralogy of Fallot patients. PMID: 26959486
- Genetic analysis of venous thromboembolism in the UK Biobank identified the ZFPM2 locus and implicated obesity as a causal risk factor. PMID: 28373160
- ZFPM2 is a glioma susceptibility gene, with its genotype and expression exhibiting associations with incidence and severity. The balancing selection acting on ZFPM2 may be related to its roles in multiple organ development or associated disease etiology. PMID: 26207917
- Isolated congenital diaphragmatic hernia was the predominant phenotype observed in patients with ZFPM2 mutations. PMID: 24702427
- A larger cohort study comprised 145 tetralogy of Fallot (TOF), 37 double-outlet ventricle outflow (DORV), and 18 transposition of the great artery (TGA) cases screened for exon mutations and copy number variations in ZFPM2/FOG2. PMID: 25025186
- Whole exome sequencing identified independent missense mutations in FOG2 in two patients with 46,XY gonadal dysgenesis. PMID: 24549039
- Findings indicate that zinc finger protein, multitype 2 protein (ZFPM2) plays a role in diaphragm and cardiovascular development. PMID: 24769157
- Art27 interacts with GATA4, FOG2, and NKX2.5 and is a novel co-repressor of cardiac genes. PMID: 24743694
- The results provide strong evidence regarding the susceptibility of the ZFPM2 gene to the development of non-syndromic TOF/DORV. PMID: 24469719
- FOG1, FOG2, and GATA-6 modulate the transcriptional up-regulation of HAMP in hepatocytes during inflammation. PMID: 24179092
- Variants of the ZFPM2/FOG2 gene might be a common cause of Double outlet right ventricle. PMID: 21919901
- Sex Cord Stromal Tumors in childhood exhibited an embryonal gonadal phenotype, expressing a FOG-2/GATA-4 pattern consistent with embryonal gonads. PMID: 23029311
- An association of the ZFPM2 SNP, rs12678719, with antipsychotic-induced parkinsonism has been observed. PMID: 21947317
- New mutations in the ZFPM2/FOG2 gene have been identified in tetralogy of Fallot and double outlet right ventricle. PMID: 20807224
- These results suggest that FOG1 and 2, along with CTBPs, act as partners of GATA proteins in regulating adipocyte proliferation and differentiation. PMID: 20705609
- FOG-2 plays a specific role in fetal ovaries, counteracting the transactivation of the mullerian-inhibiting substance gene by GATA-4. This highlights the significant role of FOG-2 and GATA transcription factors in developing ovaries. PMID: 12606418
- AML1-FOG2 and FOG2-AML1 are expressed in myelodysplastic syndrome. The findings suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of AML1 and GATA developmental programs in the disease pathogenesis. PMID: 15705784
- FOG-2 affects not only cardiac development but also gonadal function and its preservation. PMID: 17309641
- Sequence variation in diaphragmatic hernia has been identified. PMID: 17568391
- SERCA2 is a key target of FOG-2, and increased FOG-2 expression may contribute to a decline in cardiac function in end-stage heart failure due to impaired T3 signaling. PMID: 18658259
- Comparative analyses identified USH and its human homolog, FOG2, as the targets of fly miR-8 and human miR-200, respectively. USH/FOG2 inhibits PI3K activity, suppressing cell growth in both flies and humans. PMID: 20005803
Database Links
Involvement In Disease
Tetralogy of Fallot (TOF); Diaphragmatic hernia 3 (DIH3); 46,XY sex reversal 9 (SRXY9); Conotruncal heart malformations (CTHM)
Protein Families
FOG (Friend of GATA) family
Subcellular Location
Nucleus.
Tissue Specificity
Widely expressed at low level.
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