ZFX Antibody

1. MiR-493 acts as a tumor suppressor in HCC cells by regulating ZFX expression, suggesting its potential therapeutic value in HCC. PMID: 29758928
2. Depleting ZFX using lentiviral shRNAs significantly inhibited cell proliferation by inducing cell cycle arrest in the G0/G1 phase, leading to increased cell apoptosis and reduced invasion. PMID: 30007968
3. ZFX activates and maintains EpCAM(+) liver cancer stem cells by promoting nuclear translocation and transactivation of beta-catenin. The combination of ZFX and EpCAM may serve as a significant prognostic indicator for patients with hepatocellular carcinoma. PMID: 28156061
4. ZFX promotes colorectal cancer (CRC) progression by suppressing dual specificity phosphatase 5 (DUSP5) expression, suggesting its potential as a prognostic biomarker and therapeutic target in stage II/III CRC patients. PMID: 26967242
5. Colon cancer-associated transcript-1 knockdown inhibits proliferation and invasion of laryngeal squamous cell cancer cells by enhancing zinc finger protein, X-linked by sponging microRNA-218, highlighting a novel regulatory axis in laryngeal squamous cell cancer and providing a promising therapeutic target for laryngeal cancer. PMID: 28631575
6. EZH2 and ZFX genes may not significantly impact the onset of most parathyroid tumors, both benign and malignant, although further research on larger cohorts of different ethnicities is necessary. PMID: 26876532
7. Zinc finger and X-linked factor ZFX transactivates the SET transcript 2 promoter by binding to a site near the transcription start site. PMID: 27775603
8. MiR-144 functions as a tumor suppressor in hepatocellular carcinoma (HCC) cell growth and motility by directly targeting ZFX, indicating its potential applications in the development of HCC treatment. PMID: 28229969
9. ZFX is aberrantly expressed in multiple human leukemic cells and modulates the growth and drug response of leukemic cells partially via B4GALT1, suggesting it as a novel regulator of leukemic cells requiring further investigation as a 'stemness' regulator in these diseases. PMID: 27797721
10. ZFX is a novel oncogene that promotes cell proliferation and induces imatinib resistance via the PI3K/Akt signaling pathway. PMID: 26912059
11. Zinc finger protein x-linked contributes to patient prognosis and regulates cell proliferation and apoptosis in human laryngeal squamous cell carcinoma. PMID: 26823701
12. ZFX expression may be associated with poor prognosis in renal cell carcinoma patients. PMID: 26540164
13. Nasopharyngeal carcinoma patients with high ZFX expression exhibit lower 5-year overall survival rates, progression-free survival rates, loco-regional relapse-free survival rates, and distant metastasis-free survival rates compared to those with low ZFX expression. PMID: 26097576
14. ZFX overexpression is linked to the development of tongue SCC, and ZFX knockdown represents a potential treatment for tumor suppression. PMID: 25916205
15. ZFX acts as a critical upstream regulator of c-Myc and plays essential roles in maintaining the glioma stem cells phenotype. PMID: 24831540
16. ZFX is crucial for the development and progression of squamous cell carcinoma of the tongue. PMID: 25355536
17. ZFX expression is associated with the progression of colorectal cancer. PMID: 25031734
18. ZFX expression was specifically upregulated in cancer tissues at the mRNA and protein levels in 42 patients with renal cancer. PMID: 25441684
19. ZFX expression promotes tumor growth in hepatocellular carcinoma. PMID: 24585547
20. ZFX knockdown prevented tumor cell growth and migration in vitro, decreased the proportion of tumor-bearing mice, and reduced mean tumor volume in a subcutaneous tumor model. PMID: 24228108
21. ZFX is overexpressed in children with B-acute lymphoblastic leukemia, with higher levels observed in those with a poor prognosis compared to those with a good prognosis. PMID: 23866268
22. Zinc finger X-chromosomal protein promoted the growth and migration of gallbladder cancer cells. PMID: 23860324
23. ZFX plays a significant role in gastric cancer tumorigenicity and may have potential applications in the diagnosis or treatment of GC. PMID: 23587796
24. ZFX regulates glioma cell proliferation and survival. PMID: 23322077
25. ZFX may play a crucial role in cell growth control and cell cycle progression of 95D cells. PMID: 23461064
26. ZFX acts as a molecular rheostat regulating the balance between self-renewal and differentiation in human Embryonic stem cells. PMID: 22879936
27. Disseminated gastric cancer cells can survive in bone marrow when low expression of miR-144 permits upregulation of ZFX, potentially playing a key role in gastric cancer progression. PMID: 22955854
28. Zfx may play a critical role in cell proliferation, cell cycle distribution, and apoptosis of human malignant glioma cells. PMID: 22185393
29. ZFX was differentially expressed in different tumor types and grades of gastric cancer. PMID: 22357206
30. High expression of ZFX is associated with laryngeal squamous cell carcinoma progression, and knockdown of ZFX may block tumor cell growth primarily by promoting cell apoptosis. PMID: 22009483

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HGNC: 12869

OMIM: 314980

KEGG: hsa:7543

STRING: 9606.ENSP00000304985

UniGene: Hs.336681