β-hydroxybutyryl-HIST1H2BC (K11) Antibody
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In Stock 
Description
Role of HIST1H2BC and Kbhb Modification
HIST1H2BC is a core histone H2B variant involved in nucleosome assembly, DNA repair, and transcriptional regulation . β-hydroxybutyrylation (Kbhb) is a histone modification induced by β-hydroxybutyrate (BHB), a ketone body produced during fasting or ketogenic states . Kbhb modulates chromatin structure and gene expression, influencing:
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Metabolic Regulation: BHB levels directly correlate with histone Kbhb, linking cellular metabolism to epigenetic states .
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Disease Pathways: Altered Kbhb levels are implicated in cancer, sarcopenia, and metabolic disorders .
Key Research Applications
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Studying mitochondrial dysfunction and muscle atrophy (sarcopenia) .
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Validating specificity of Kbhb antibodies in cell models (e.g., HEK293, C2C12 myotubes) .
Key Experimental Data
Limitations and Considerations
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship products within 1-3 business days after receiving your order. Delivery times may vary depending on the method of purchase and location. Please contact your local distributor for specific delivery times.
Synonyms
H2BC4 antibody; H2BFL antibody; HIST1H2BC; antibody; H2BC6 antibody; H2BFH antibody; HIST1H2BE; antibody; H2BC7 antibody; H2BFG antibody; HIST1H2BF; antibody; H2BC8 antibody; H2BFA antibody; HIST1H2BG; antibody; H2BC10 antibody; H2BFK antibody; HIST1H2BIHistone H2B type 1-C/E/F/G/I antibody; Histone H2B.1 A antibody; Histone H2B.a antibody; H2B/a antibody; Histone H2B.g antibody; H2B/g antibody; Histone H2B.h antibody; H2B/h antibody; Histone H2B.k antibody; H2B/k antibody; Histone H2B.l antibody; H2B/l antibody
Target Names
HIST1H2BC
Uniprot No.
Target Background
Function
This antibody targets β-hydroxybutyryl-HIST1H2BC (K11), a core component of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to cellular machinery that utilizes DNA as a template. Consequently, histones play a crucial role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated through a complex set of post-translational modifications of histones, often referred to as the histone code, and nucleosome remodeling. Additionally, β-hydroxybutyryl-HIST1H2BC (K11) exhibits broad antibacterial activity. It may contribute to the formation of the functional antimicrobial barrier of the colonic epithelium and the bactericidal activity of amniotic fluid.
Database Links
Protein Families
Histone H2B family
Subcellular Location
Nucleus. Chromosome.
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