Chicken Serum Transferrin

Iron Homeostasis

• Transports Fe³⁺ from absorption sites (intestine, liver) to proliferating cells

• Serum levels inversely correlate with body iron status:

  • ↑ 300% in iron deficiency

  • ↓ 50% in iron overload

Myotrophic Activity

• Promotes skeletal muscle differentiation through:

  • 32% increase in acetylcholine receptor density

  • 41% elevation in acetylcholinesterase activity

• Essential for embryonic myogenesis, showing developmental activity patterns:

  • Low until embryonic day 14

  • Peak activity at hatching (day 21)

Immune Modulation

• Acute-phase reactant: Decreases 51% during LPS-induced inflammation (2 mg/kg challenge)

• Exhibits bacteriostatic activity through iron sequestration and direct membrane interactions

Experimental Findings

Table 2: Proteomic changes in LPS-challenged chickens

Data from 72-hour post-LPS analysis (n=6)

Key muscle culture results:

• 89% myoblast fusion index with 100 μg/mL transferrin vs 42% in controls

• Maintains protein synthesis rates equivalent to embryo extract-supplemented media

Research Applications

• Cell Culture: Essential component for avian myocyte differentiation media

• Diagnostics: Commercial ELISA kits detect 85-115% recovery in serum/plasma

• Therapeutic Potential:

  • Peptide derivatives show antioxidant capacity 3.2-13.5× baseline

  • Demonstrated ACE-inhibitory activity (IC₅₀=9.1 μM) in hypertensive models