GLP-1 Human (31 a.a.)

Glucagon Like Peptide-1 (31 a.a.) Human Recombinant
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Cat. No.
BT13786
Source
Escherichia Coli.
Synonyms
GLP1, GLP2, GRPP.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Glucagon Like Peptide-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 31 amino acids and having a molecular mass of 3298.7 Dalton. The GLP-1 is purified by proprietary chromatographic techniques.

Product Specs

Introduction
Glucagon-like peptide-1 (GLP-1) is a naturally occurring hormone produced in the intestines. It plays a crucial role in regulating blood sugar levels by stimulating insulin release from the pancreas when blood sugar is high. GLP-1 also slows down gastric emptying, reduces appetite, and promotes the growth of insulin-producing cells in the pancreas.
Description
This product consists of the active fragment (31 amino acids) of human GLP-1, produced through recombinant technology in E. coli bacteria. It is a non-glycosylated polypeptide with a molecular weight of 3298.7 Daltons. The GLP-1 is purified using specialized chromatographic methods.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
The GLP-1 is provided as a lyophilized powder. It was initially prepared as a concentrated solution (1mg/ml) and then freeze-dried after extensive dialysis against a buffer solution containing sodium phosphate monobasic & sodium phosphate dibasic.
Solubility
To reconstitute the lyophilized GLP-1, it is recommended to dissolve it in sterile 18 megaohm-cm water at a concentration of at least 100 micrograms per milliliter. This solution can be further diluted in other aqueous solutions as needed.
Stability
The lyophilized GLP-1 remains stable at room temperature for up to 3 weeks; however, it is recommended to store it desiccated below -18 degrees Celsius for long-term storage. Once reconstituted, GLP-1 should be stored at 4 degrees Celsius and used within 2-7 days. For extended storage, adding a carrier protein (0.1% HSA or BSA) is recommended. Avoid repeated freeze-thaw cycles to maintain product integrity.
Purity
The purity of GLP-1 is greater than 95%, confirmed by two analytical methods: (a) Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) and (b) Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE).
Synonyms
GLP1, GLP2, GRPP.
Source
Escherichia Coli.
Amino Acid Sequence
HAEGTFTSDV SSYLEGQAAK EFIAWLVKGR G.

Product Science Overview

Introduction

Glucagon-like peptide-1 (GLP-1) is a peptide hormone consisting of 30-31 amino acids. It is derived from the tissue-specific post-translational processing of the proglucagon peptide . GLP-1 plays a crucial role in regulating glucose metabolism and has significant therapeutic potential for treating type 2 diabetes and obesity . The human recombinant form of GLP-1 is synthesized to mimic the natural hormone’s effects, providing a valuable tool for research and therapeutic applications.

Production and Secretion

GLP-1 is produced and secreted by intestinal enteroendocrine L-cells in response to nutrient ingestion . It is also secreted by certain neurons within the nucleus of the solitary tract in the brainstem . The secretion of GLP-1 is stimulated by both nutritional and inflammatory stimuli .

Functions and Mechanisms

GLP-1 functions as an incretin hormone, enhancing glucose-dependent insulin secretion from pancreatic beta cells and inhibiting glucagon release from alpha cells . It also slows gastric emptying, which helps regulate postprandial blood glucose levels . Additionally, GLP-1 has been shown to have anti-inflammatory properties, protecting cells from damage and apoptosis .

Therapeutic Applications

The therapeutic potential of GLP-1 has been recognized in various medical conditions. GLP-1 receptor agonists, such as liraglutide, are used to treat type 2 diabetes and obesity by improving glycemic control and promoting weight loss . Recent studies have also explored the use of GLP-1 receptor agonists in treating headache and pain disorders, highlighting their expanding therapeutic scope .

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THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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