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Monoclonal Antibodies

Other Monoclonal Antibodies

Anti Human Lymphocyte

Anti Mouse Cytokine

Anti Human Cytokine

Anti Mouse Lymphocyte

Anti-GST Monoclonal

Anti Viral Monoclonal

Anti Human Heat Shock Protein

Anti Human Enzyme

Product List

MOG Antibody

myelin oligodendrocyte glycoprotein, Mouse Antibody

Shipped with Ice Packs

Cat. No.

BT26014

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MYD88 Antibody

Myeloid Differentiation Primary Response 88, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT26713

Appearance

Colorless, sterile-filtered solution.

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MYL2 Antibody

Myosin Light Chain 2, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT26790

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MYL4 Antibody

Myosin Light Chain 4, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT26878

Appearance

The product is a colorless solution that has undergone sterile filtration.

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Myoglobin Antibody

Myoglobin, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT26976

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NANOG Antibody

Homeobox Protein NANOG, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT27040

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OTUB2 Antibody

Mouse Anti Human Ubiquitin Aldehyde Binding 2

Shipped with Ice Packs

Cat. No.

BT28257

Appearance

A clear, sterile-filtered solution.

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p53 Antibody

p53, Mouse Antibody

Mouse monoclonal antibodies are generated through immunization with the full-length His-tagged p53 protein.

Shipped with Ice Packs

Cat. No.

BT28337

Appearance

Sterile filtered solution.

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p53 scFv antibody

p53 scFv Recombinant Antibody

p53, also known as TP53, is a transcription factor with a critical role in cell cycle regulation. Upon activation by DNA damage or cellular stress, p53 initiates the transcription of genes that induce cell cycle arrest or apoptosis, effectively acting as a tumor suppressor. Mutations in this gene are prevalent in approximately half of all human cancers. The recombinant Anti p53 antibody, produced in E. coli, is a non-glycosylated polypeptide chain with a hexahistidine tag, exhibiting a molecular weight of 37 kDa. The purification of rAp53 is achieved through proprietary chromatographic methods.

Shipped with Ice Packs

Cat. No.

BT28417

Source

Escherichia Coli.

Appearance

Clear solution, sterile-filtered.

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PA2G4 Antibody

Proliferation-associated protein 2G4, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT28497

Appearance

Sterile filtered colorless solution.

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Introduction

Definition and Classification

Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are produced by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can be classified based on their source and structure:

Murine mAbs: Derived from mouse cells.
Chimeric mAbs: Contain both human and mouse components.
Humanized mAbs: Mostly human, with only small mouse-derived components.
Human mAbs: Fully human antibodies.

Biological Properties

Monoclonal antibodies exhibit several key biological properties:

Protein Sequence: Identical protein sequences and antigen-binding sites.
Expression Patterns: Produced by B lymphocytes and expressed in hybridoma cells.
Tissue Distribution: Can be designed to target specific tissues or cells, such as cancer cells.

Biological Functions

Monoclonal antibodies play crucial roles in the immune system:

Pathogen Recognition: Bind to specific antigens on pathogens, marking them for destruction.
Immune Response: Enhance the immune system’s ability to fight infections and diseases.
Therapeutic Functions: Used in treating various diseases, including cancer, autoimmune disorders, and infectious diseases.

Modes of Action

Monoclonal antibodies interact with other molecules and cells through various mechanisms:

Binding Partners: Bind to specific antigens on target cells.
Downstream Signaling Cascades: Trigger immune responses by activating immune cells and complement systems.
Effector Functions: Engage Fc receptors on immune cells, leading to cell-mediated cytotoxicity.

Regulatory Mechanisms

The expression and activity of monoclonal antibodies are tightly regulated:

Transcriptional Regulation: Controlled by specific transcription factors that regulate the expression of antibody genes.
Post-Translational Modifications: Undergo modifications such as glycosylation, which can affect their stability and function.

Applications

Monoclonal antibodies have a wide range of applications in biomedical research and medicine:

Diagnostic Tools: Used in assays to detect specific antigens in samples.
Therapeutic Strategies: Employed in the treatment of cancers, autoimmune diseases, and infectious diseases.
Biomedical Research: Serve as tools to study cellular processes and disease mechanisms.

Role in the Life Cycle

Monoclonal antibodies play roles throughout the life cycle:

Development: Used in prenatal diagnostics and treatments.
Aging: Help manage age-related diseases such as cancer and Alzheimer’s.
Disease: Provide targeted therapies for various diseases, improving patient outcomes.