CoV2 Paired Antibody

Mouse Anti SARS CoV-2 Paired

This product consists of a pair of SARS CoV2 antibodies: a coating antibody (C865) and a conjugating antibody (C866), both targeting the CoV2 nucleoprotein. Designed specifically for the development of CoV2 antigen rapid tests, these antibodies facilitate the detection of CoV-2 nucleoprotein. Notably, they exhibit high specificity and do not cross-react with CoV nucleoproteins from 229E, HKU1, NL63, or OC43. CoV2 antigen rapid tests prepared using this antibody pair demonstrate a detection sensitivity of 5ng/ml for recombinant SARS-CoV2 nucleoprotein.
It is important to note that when ordering a specific quantity, for instance, 100µg of antibody, the shipment will contain 50µg of each antibody, totaling 100µg.

Shipped with Ice Packs
Cat. No.
BT5814
Appearance

The product is provided as two vials containing sterile filtered, clear, and colorless solutions.

Dengue Control Antibody

Monoclonal Mouse Anti Dengue Control for Lateral Flow Test

Monoclonal Mouse Anti Dengue Control for Lateral Flow Test. This antibody is used to prepare a control line for dengue IgG/IgM rapid tests. The recommended coating concentration is 0.4-0.5mg/ml, 1µl/cm.
Shipped with Ice Packs
Cat. No.
BT5881
Appearance
Clear, colorless, and sterile-filtered solution.

Dengue NS1 Antibody

Monoclonal Mouse Anti Dengue NS1

This product consists of two monoclonal antibodies designed for use in a dengue NS1 antigen lateral flow immunoassay. The first antibody is intended for conjugation, while the second antibody is meant for membrane coating. When ordering, for instance, 100µg of antibody, you will receive 50µg of each antibody solution (totaling 100µg).
Shipped with Ice Packs
Cat. No.
BT5970
Appearance
This product is supplied as two vials containing a clear, colorless solution that has been sterile filtered.

Dengue NS1 Paired Antibody

Mouse Anti Dengue NS1 Paired

This product contains a pair of monoclonal antibodies specifically designed for use in a dengue NS1 antigen lateral flow immunoassay. For optimal results, it is recommended to use a gold concentration of 10 µg/ml (with an OD of 1.2-1.5) for conjugation with the clone 24/c antibody. The suggested coating concentration for the clone 2/b antibody is 1.2 µg/cm. It's important to note that the sensitivity of the assay is directly proportional to the optical density of the conjugated gold. The test typically requires a sample volume of 80-90 µl. When tested using samples with an OD over 5, the rapid test developed with these paired antibodies demonstrated a sensitivity of 90%. The sensitivity decreased to 60% for samples with an OD below 5 when analyzed by ELISA. It is important to note that when ordering a specific quantity, for example, 100 µg of antibody, the shipment will contain 50 µg of each antibody, totaling 100 µg.
Shipped with Ice Packs
Cat. No.
BT6120
Appearance
This product consists of two vials containing a sterile, filtered, clear, and colorless solution.

HCV Core Antibody

Hepatitis C Virus Core, Mouse antibody

Shipped with Ice Packs
Cat. No.
BT7014
Source
Protein-A.

HCV NS3 antibody

Hepatitis C Virus NS3, Mouse antibody

This is a monoclonal antibody targeting the NS3 protein of the Hepatitis C Virus (HCV).
Shipped with Ice Packs
Cat. No.
BT7106
Appearance
This antibody comes in the form of a sterile, filtered, white powder that has been lyophilized (freeze-dried).

Hepatitis B antibody

Hepatitis B (AD & AY Antigens), Mouse antibody

Shipped with Ice Packs
Cat. No.
BT7165

Hepatitis B Core antibody

Hepatitis B Core, Mouse antibody

Shipped with Ice Packs
Cat. No.
BT7235
Appearance
Sterile solution.

HSV2 gB Antibody

HSV-2 gB, Mouse Anti Human

Shipped with Ice Packs
Cat. No.
BT8047

Influenza-A Paired Antibody

Mouse Anti Influenza-A Paired

This product contains a pair of antibodies designed for use in Influenza-A rapid tests. It includes an Influenza-A gold conjugation antibody and an Influenza-A capture antibody. When ordering, the total quantity represents the combined amount of both antibodies. For example, an order of 100µg will contain 50µg of each antibody.
Shipped with Ice Packs
Cat. No.
BT8421
Appearance
Two vials containing a sterile, filtered solution. The solution is clear and colorless.
Definition and Classification

Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are designed to bind to antigens that are generally more specific than polyclonal antibodies . Anti-viral monoclonal antibodies are a subset of mAbs specifically designed to target and neutralize viruses. These antibodies can be classified based on their source (e.g., murine, chimeric, humanized, or fully human) and their mechanism of action (e.g., neutralizing vs. non-neutralizing) .

Biological Properties

Anti-viral monoclonal antibodies exhibit several key biological properties:

  • Expression Patterns: These antibodies are typically produced in mammalian cell lines such as CHO (Chinese Hamster Ovary) cells, which allow for proper folding and post-translational modifications .
  • Tissue Distribution: Once administered, mAbs distribute throughout the body, with a significant presence in the bloodstream and tissues where the targeted virus is likely to be found .
Biological Functions

The primary biological functions of anti-viral monoclonal antibodies include:

  • Immune Response: They enhance the immune response by binding to viral antigens and marking them for destruction by immune cells .
  • Pathogen Recognition: These antibodies recognize and bind to specific viral proteins, preventing the virus from entering host cells and replicating .
Modes of Action

Anti-viral monoclonal antibodies operate through several mechanisms:

  • Binding Partners: They bind to viral surface proteins, such as the spike protein of SARS-CoV-2, blocking the virus from attaching to host cell receptors .
  • Downstream Signaling Cascades: Upon binding to the virus, these antibodies can trigger downstream signaling pathways that lead to the activation of immune cells and the destruction of the virus .
Regulatory Mechanisms

The expression and activity of anti-viral monoclonal antibodies are tightly regulated:

  • Transcriptional Regulation: The genes encoding these antibodies are often placed under the control of strong promoters to ensure high levels of expression in production cell lines .
  • Post-Translational Modifications: These antibodies undergo various post-translational modifications, such as glycosylation, which are crucial for their stability and function .
Applications

Anti-viral monoclonal antibodies have a wide range of applications:

  • Biomedical Research: They are used to study viral infections and the immune response to these infections .
  • Diagnostic Tools: mAbs are employed in diagnostic assays to detect the presence of viruses in clinical samples .
  • Therapeutic Strategies: These antibodies are used as treatments for viral infections, either alone or in combination with other antiviral agents .
Role in the Life Cycle

Throughout the life cycle, anti-viral monoclonal antibodies play crucial roles:

  • Development: During development, these antibodies can be used to study the immune response to viral infections and to develop vaccines .
  • Aging and Disease: In aging populations and individuals with compromised immune systems, mAbs can provide passive immunity and help control viral infections .
© Copyright 2024 Thebiotek. All Rights Reserved.