Monoclonal Antibodies
Product List
HIV-1 p24 Paired
Mouse Anti HIV-1 p24 Paired
These HIV-1 p24 Paired antibodies are designed for lateral flow immunoassays and have a molecular weight of 24kDa. One antibody is intended for coating, while the other is for conjugation purposes. When ordering, for instance, 100µg of antibody, you will receive two vials: one containing 50µg of the coating antibody and the other containing 50µg of the conjugating antibody, totaling 100µg.
Influenza-A H5N1 Antibody
Influenza-A Hemagglutinin H5N1, Mouse Antibody
A clear, colorless solution that has been sterilized by filtration.
SARS MERS Spike S1
Mouse Anti SARS MERS Spike S1
SARS Nucleocapsid Biotin Antibody
Mouse Anti SARS Nucleocapsid Biotinylated
The SARS Nucleoprotein Biotinylated antibody, specifically clone PT3851, demonstrates specificity for the nucleocapsid protein of SARS-CoV. Furthermore, it exhibits recognition of the SARS-CoV-2 nucleoprotein in ELISA assays.
RSV Paired Antibody
Mouse Anti Human Respiratory Syncytial Virus
Introduction
Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are designed to bind to antigens that are generally more specific than polyclonal antibodies . Anti-viral monoclonal antibodies are a subset of mAbs specifically designed to target and neutralize viruses. These antibodies can be classified based on their source (e.g., murine, chimeric, humanized, or fully human) and their mechanism of action (e.g., neutralizing vs. non-neutralizing) .
Anti-viral monoclonal antibodies exhibit several key biological properties:
- Expression Patterns: These antibodies are typically produced in mammalian cell lines such as CHO (Chinese Hamster Ovary) cells, which allow for proper folding and post-translational modifications .
- Tissue Distribution: Once administered, mAbs distribute throughout the body, with a significant presence in the bloodstream and tissues where the targeted virus is likely to be found .
The primary biological functions of anti-viral monoclonal antibodies include:
Anti-viral monoclonal antibodies operate through several mechanisms:
- Binding Partners: They bind to viral surface proteins, such as the spike protein of SARS-CoV-2, blocking the virus from attaching to host cell receptors .
- Downstream Signaling Cascades: Upon binding to the virus, these antibodies can trigger downstream signaling pathways that lead to the activation of immune cells and the destruction of the virus .
The expression and activity of anti-viral monoclonal antibodies are tightly regulated:
- Transcriptional Regulation: The genes encoding these antibodies are often placed under the control of strong promoters to ensure high levels of expression in production cell lines .
- Post-Translational Modifications: These antibodies undergo various post-translational modifications, such as glycosylation, which are crucial for their stability and function .
Anti-viral monoclonal antibodies have a wide range of applications:
- Biomedical Research: They are used to study viral infections and the immune response to these infections .
- Diagnostic Tools: mAbs are employed in diagnostic assays to detect the presence of viruses in clinical samples .
- Therapeutic Strategies: These antibodies are used as treatments for viral infections, either alone or in combination with other antiviral agents .
Throughout the life cycle, anti-viral monoclonal antibodies play crucial roles:
